Hepatic synthesis of apoproteins of very low density and high density lipoproteins in perfused rat liver: influence of chronic heavy and moderate doses of ethanol

Alcoholism, Clinical and Experimental Research
M R LakshmanB S Campbell

Abstract

The effects of 6 weeks of heavy and moderate ethanol feeding to rats upon lipids and lipoprotein metabolism were determined. As compared to the control group, the heavy ethanol feeding resulted in the following changes: liver weight/kilogram body weight increased by 48% (p less than 0.001) with a concomitant 52% increase (p less than 0.001) in liver protein/kilogram body weight and a 2.75-fold (p less than 0.001) increase in liver total lipids/kilogram body weight. In contrast, liver DNA/kilogram body weight or per liver was not affected significantly. Plasma cholesterol and triglycerides were higher by 53% (p less than 0.01) and 77% (p less than 0.01), respectively. Liver cholesterol and triglycerides were 4.4-fold and 3.8-fold higher (p less than 0.001), respectively. Plasma total A1 was 1.72-fold higher (p less than 0.001), whereas there was no significant difference in plasma apo E levels between the two groups. However, plasma high density lipoproteins (HDl) apo E was 48% lower (p less than 0.02) while the very low density lipoproteins (VLDL) E was 2.15-fold higher (p less than 0.02). Hepatic total protein synthetic rate in the ethanol group was not significantly different from the control group. In contrast, labeled leuci...Continue Reading

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Citations

Mar 10, 2004·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Morten Grønbaek
Sep 29, 2001·Journal of Internal Medicine·M Grønbaek
Jan 13, 2006·Current Opinion in Lipidology·Morten Grønbaek
Oct 1, 1993·Alcoholism, Clinical and Experimental Research·V T SavolainenP J Karhunen
Feb 1, 1997·Alcoholism, Clinical and Experimental Research·P Ghosh, M R Lakshman
Jun 1, 1997·Alcoholism, Clinical and Experimental Research·M J LiinamaaM J Savolainen
Jul 24, 2015·Hepatology International·M Raj LakshmanRuchi Shah
Jul 1, 1995·Metabolism: Clinical and Experimental·P GhoshM R Lakshman
Jun 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·A ShaishG Schonfeld
Aug 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H K SeitzU A Simanowski
Apr 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R C LinT J Kelly
Mar 1, 1991·Alcoholism, Clinical and Experimental Research·R C Lin, L Lumeng
Aug 1, 1991·Alcoholism, Clinical and Experimental Research·P GhoshM R Lakshman
Jun 1, 1993·Alcoholism, Clinical and Experimental Research·P GhoshM R Lakshman

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