Hepatic thyroid signaling of heat-stressed late pregnant and early lactating cows

The Journal of Endocrinology
Joachim WeitzelB Kuhla

Abstract

During the transition between late gestation and early lactation, dairy cows experience severe metabolic stress due to the high energy and nutrient requirements of the fetus and the mammary gland. Additional thermal stress that occurs with rising temperatures during the ongoing climate change has further adverse implications on energy intake, metabolism and welfare. The thyroid hormone (TH)-mediated cellular signaling has a pivotal role in regulation of body temperature, energy intake and metabolic adaptation to heat. To distinguish between energy intake and heat stress-related effects, Holstein cows were first kept at thermoneutrality at 15°C followed by exposure to heat stress (HS) at 28°C or pair-feeding (PF) at 15°C for 6 days, in late pregnancy and again in early lactation. Herein, we focused on hepatic metabolic changes associated with alterations in the hypothalamic-pituitary-thyroid axis in HS and PF animals. T3 and T4 levels dropped with HS or PF; however, in HS animals, this decline was more pronounced. Thyroid-stimulating hormone (TSH) levels remain unaffected, while plasma cholesterol concentrations were lower in HS than PF animals. Hepatic marker genes for TH action (THRA, DIO1 and PPARGC1) decreased after HS and w...Continue Reading

References

Jul 3, 2003·Journal of Dairy Science·J W West
Oct 2, 2003·Journal of Molecular Endocrinology·J M WeitzelH J Seitz
Mar 14, 2008·Molecular and Cellular Endocrinology·Anne WulfJoachim M Weitzel
Jan 7, 2010·Endocrine Reviews·Sheue-Yann ChengPaul J Davis
Jan 29, 2010·Journal of Dairy Science·J B WheelockL H Baumgard
Oct 1, 2010·Endocrine Reviews·S PiehlJ Köhrle
Jun 15, 2011·Molecular and Cellular Endocrinology·Joachim M Weitzel, K Alexander Iwen
Jul 18, 2012·Biochimica Et Biophysica Acta·Inna Astapova, Anthony N Hollenberg
Jun 19, 2013·Molecular and Cellular Endocrinology·Federica CioffiFernando Goglia
Sep 10, 2013·Thyroid : Official Journal of the American Thyroid Association·Paul J DavisShaker A Mousa
Sep 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Amy WarnerJens Mittag
Apr 3, 2014·Physiological Reviews·Rashmi MullurGregory A Brent
Jan 9, 2015·The Journal of Experimental Biology·Kenneth B Storey
Sep 30, 2015·Nature Reviews. Endocrinology·Balázs GerebenAntonio C Bianco

❮ Previous
Next ❯

Citations

Jan 8, 2020·Thyroid : Official Journal of the American Thyroid Association·Scott A Ochsner, Neil J McKenna
Aug 25, 2018·Animal : an International Journal of Animal Bioscience·V SejianN Lacetera
Mar 8, 2020·Tropical Animal Health and Production·Wilian Aparecido Leite da SilvaFabiana de Andrade Melo-Sterza
Apr 3, 2020·Animals : an Open Access Journal From MDPI·Hanfang ZengZhaoyu Han
Mar 17, 2020·Theriogenology·Sha TaoJohn K Bernard

❮ Previous
Next ❯

Methods Mentioned

BETA
targeted gene mutation
ELISA
biopsies
biopsy
electrophoresis
PCR
glycosylation

Software Mentioned

ImageJ
4000 Series Explorer
Magellan
Mascot
STAT
Delta2D
SAS

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.