Hepatic transport of the magnetic resonance imaging contrast agent gadobenate dimeglumine in the rat

Academic Radiology
C de HaënP Tirone

Abstract

Gadobenate dimeglumine is a new octadentate gadolinium (III) complex salified with meglumine. The compound is currently under evaluation as an intravenously administered paramagnetic contrast agent for magnetic resonance (MR) imaging. We investigated the mechanisms involved in the biliary excretion of gadobenate ion, the contrast-effective ion in gadobenate dimeglumine. Biliary and urinary excretion of gadobenate ion injected intravenously to rats at 0.25 mmol/kg was studied following pretreatment with bromosulfophthalein (BSP) disodium salt, sodium taurocholate (TC), or oxyphenonium bromide (OP) and at various times after common bile duct ligation. Gadobenate ion was assayed by high-pressure liquid chromatography in bile and urine. Plasma bilirubin levels after duct ligation were measured by colorimetric assay. The 90-min excretion of gadobenate ion into bile accounted for 35.5 +/- 3.7% and excretion into urine for 45.7 +/- 3.5% of the injected dose (mean +/- SD). Pretreatment with BSP reduced recovery of the compound in bile to less than 1% and increased urinary excretion to 65.6 +/- 4.7%. Gadobenate dimeglumine had a substantial choleretic effect that was completely abolished by pretreatment with BSP. Pretreatment with TC an...Continue Reading

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Citations

Jul 18, 2002·Journal of Inorganic Biochemistry·M I M PrataJ J P de Lima
Nov 18, 1998·Investigative Radiology·M A KirchinA Spinazzi
Aug 29, 2003·Radiology·Catherine M PastorJean-Paul Vallee
Dec 17, 2011·European Journal of Pharmacology·Bruno StiegerThomas van Gulik
Aug 1, 1996·Academic Radiology·C de HaënP Tirone
Dec 8, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Simona BussiAlberto Morisetti
Sep 25, 2004·Journal of Magnetic Resonance Imaging : JMRI·Jui-Sheng HsuKun-Bow Tsai
Apr 20, 1999·Biochemical and Biophysical Research Communications·L PascoloC Tiribelli
Sep 16, 2020·Investigative Radiology·Michael F Tweedle

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