Hepatic venous pressure gradient in the preoperative assessment of patients with resectable hepatocellular carcinoma

Journal of Hepatology
Alessandro CucchettiAntonio Daniele Pinna

Abstract

To assess the relationship existing between hepatic venous pressure gradient (HVPG) and the occurrence of post-hepatectomy liver failure (PHLF) grade B/C after resection of hepatocellular carcinoma (HCC) and persistent worsening of liver function. Data from 70 consecutive prospectively enrolled HCC patients undergoing resection were collected and analysed. PHLF grade B/C was defined by the International Study Group of Liver Surgery recommendations. The appearance of unresolved decompensation was also analysed. Postoperative and 90-day mortality were null. The median HVPG value was 9mmHg (range: 4-18) and the median Model for End-stage Liver Disease (MELD) score was 8 (range: 6-14); 34 patients had an HVPG ⩾10mmHg (48.6%). Forty-nine patients had an uneventful (Grade A) postoperative course, including 17 with an HVPG ⩾10mmHg (24.2% of 70 patients). Grade B complications occurred in 20 patients (3 with an HVPG <10mmHg and 17 with an HVPG ⩾10mmHg; p<0.001); only one grade C complication occurred in a patient with an HVPG <10mmHg, subsequently successfully undergoing liver transplantation. Median MELD score returned to preoperative values after a transient postoperative increase, regardless of the HVPG values; after three months, i...Continue Reading

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Citations

Sep 30, 2016·Journal of Hepatology·Alessandro VitaleTimothy M Pawlik
Oct 21, 2016·BBA Clinical·Jian-Hong ZhongTian Yang
Oct 19, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sasan RoayaieLewis R Roberts
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Oct 5, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Daniel Zamora-ValdesDavid M Nagorney
Jul 12, 2018·European Journal of Gastroenterology & Hepatology·Chung-Yu ChangJaw-Ching Wu
Aug 7, 2018·Annals of Surgery·Antonio Daniele PinnaAlessandro Cucchetti
Dec 19, 2018·Journal of Surgical Oncology·Giovanni MarascoDavide Festi
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Jul 28, 2016·Annals of Surgery·Jian-Hong ZhongTian Yang
Jul 11, 2020·Journal of the Chinese Medical Association : JCMA·Hsiao-Sheng LuMing-Chih Hou
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Nov 10, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Chuan LiLu-Nan Yan
Mar 16, 2017·World Journal of Gastroenterology : WJG·Alessandro CucchettiVincenzo Mazzaferro
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Nov 20, 2020·Journal of Hepatology·Nicolas GolseIrene E Vignon-Clementel
Mar 6, 2021·Journal of Hepatology·Jitao WangXiaolong Qi
Mar 30, 2021·Hepatic Medicine : Evidence and Research·Elton DajtiFrancesco Azzaroli
Apr 29, 2021·European Journal of Gastroenterology & Hepatology·Mahmoud A ElkerdawyMohamed H Emara

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