Hepatic Vitamin A Concentrations in Vervets (Chlorocebus aethiops ) Supplemented with Carotenoids Derived from Oil Palm

Journal of the American Association for Laboratory Animal Science : JAALAS
Stephanie J MondlochPaul J van Jaarsveld

Abstract

Commonly used in biomedical research, vervets (Chlorocebus aethiops) are omnivorous but primarily meet their vitamin A requirements from provitamin A carotenoids. Hypervitaminosis A has occurred in vervets that consume feed high in preformed vitamin A. We investigated the vitamin A status of vervets supplemented daily with various antioxidants derived from palm oil. Male vervets (n = 40) were placed for 23 wk on a high-fat diet (34.9% energy) containing 645 μ g retinol activity equivalents (RAE), with 515 μ g RAE from preformed vitamin A. Vervets were randomized to 5 treatments (duration, 20 mo): control; 100 mg d-α-tocopheryl acetate; 100 mg oil palm (Elaeis guineensis)-derived vitamin E; 50 mg oil palm-derived vitamin E + 50 mg carotenoid complex + unrestricted palm-derived water-soluble antioxidants; and 5) unrestricted water-soluble antioxidants. Livers (n = 38) were analyzed for vitamin A, α-retinol (α-vitamin A), and carotenoids. Median hepatic vitamin A and total carotenoid concentrations were 6.49 μ mol/g and 4.30 nmol/g, respectively. Compared with controls, vervets fed the carotenoid complex had higher hepatic vitamin A (11.9 ± 5.1 μ mol/g), α -vitamin A (1.3 ± 0.7 μ mol/g), α -carotene (11.5 ± 5.3 nmol/g), β-carotene...Continue Reading

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