PMID: 8953668Jan 1, 1996Paper

Hepatitis A vaccination by intracutaneous low dose administration: a less expensive alternative

Scandinavian Journal of Infectious Diseases
U CarlssonB G Hansson

Abstract

We investigated the immune response to three different intracutaneous (i.c.) doses of inactivated hepatitis A vaccine: 72, 144, and 216 ELISA units (EU). The response was measured using a quotient score derived from a commercial enzyme-linked immunosorbent assay (HAVAB Abbott) and translated to IU per liter using a World Health Organization standard serum for hepatitis A virus antibody. The results were compared with the results obtained after an intramuscular (i.m.) full dose, i.e. 1,440 EU, at 0 and 6-12 months. As estimated from antibody concentration, 3 lots of 144 EU i.c. with 100% or two lots of 216 EU i.c. with 98% seroconversion results in at least as good early protection as the standard immunization with one lot of 1,440 EU i.m., (79% with our method). Indeed, only two doses of 144 EU vaccine (90% seroconversion) seem to give results comparable to the standard procedure. After the booster dose the median antibody concentration is 1,290 IU/l for the 144 EU vaccine and 837 for the 216 EU one, compared with an antibody response of 990 IU/l for the standard 1,440 EU i.m. vaccination. In conclusion, three doses of 144 EU vaccine i.c. or, as an alternative, two doses of 216 EU at monthly intervals give good early protection...Continue Reading

Citations

Jun 10, 1998·Lancet·R S Koff
Oct 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chitsanu PancharoenChristian Herzog
May 20, 2008·Vaccine·Paul Henri Lambert, Philippe E Laurent
Nov 26, 2009·Journal of Travel Medicine·Gert FrösnerChristian Herzog
Jun 22, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pål JohansenBruno Gander
Sep 9, 2020·Travel Medicine and Infectious Disease·Jenny L SchnyderMartin P Grobusch

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