Hepatitis A virus infections associated with clotting factor concentrate in the United States

Transfusion
J M SoucieB Evatt

Abstract

Two cases of hepatitis A among persons exposed to the same lot of solvent/detergent-treated antihemophilic factor VIII concentrate were reported to a surveillance system. An investigation was conducted to find additional cases and determine the source of infection. A seroprevalence study was conducted among persons with exposure to the suspect lot for serologic evidence of recent infection with hepatitis A virus (HAV). Six cases of recent HAV infection were discovered: four of the patients had been infused with material from the suspect lot of factor VIII, and two had received infusions of factor IX concentrate made from plasma pools common to the suspect factor VIII lot. HAV was identified in one of the plasma pools, in the factor VIII product, and in serum or stool from two factor VIII recipients and one factor IX recipient. The genetics sequence of the virus in the plasma pool, the factor VIII lot, and the factor VIII recipients were identical, while that of the virus in the factor IX recipient differed by a single base. These data document the transmission of HAV by a factor VIII concentrate and implicate factor IX products manufactured from a common source-plasma pool.

Citations

Dec 19, 2001·Journal of Medical Virology·Vanessa S de PaulaAna M C Gaspar
Mar 23, 2005·Médecine et maladies infectieuses·A BrunetS Abad
May 15, 2003·Vaccine·Elisabetta FrancoAlessandro R Zanetti
Mar 17, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·V S de PaulaA M C Gaspar
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·J M Teitel
Jan 3, 2001·Haemophilia : the Official Journal of the World Federation of Hemophilia·E P Mauser-BunschotenH M van den Berg
Mar 22, 2001·Haemophilia : the Official Journal of the World Federation of Hemophilia·C S Philipp, UNKNOWN Monoclate-P Study Group
Feb 1, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·E Alonso-RubianoC Leissinger
Nov 4, 2000·Journal of Gastroenterology and Hepatology·O S KwonC H Lee
Jan 19, 2006·Clinical Microbiology Reviews·Omana V NainanHarold S Margolis
Aug 16, 2002·Sexually Transmitted Infections·M G Brook
Jul 13, 2004·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Paul L F Giangrande
Feb 1, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·T Burnouf, M Radosevich
Jul 26, 2000·American Journal of Epidemiology·Y J HutinB P Bell
Aug 10, 2005·Expert Opinion on Pharmacotherapy·Paul Giangrande
May 25, 2004·Expert Opinion on Pharmacotherapy·Natalya AnanyevaEvgueni Saenko
Nov 22, 2000·Annals of Medicine·B Horowitz, E Ben-Hur
Apr 26, 2016·Hepatitis Monthly·Khashayar HesamizadehMaryam Keshvari
Apr 2, 2010·American Journal of Preventive Medicine·Sean R TrimbleNimia Reyes
Oct 27, 2004·Transfusion·Peter GowlandBehrouz Mansouri Taleghani
Mar 29, 2003·Transfusion·A Hafeez DiwanGary E Carnahan
Sep 26, 2006·Journal of Medical Virology·Grace M S TjonSylvia M Bruisten
Nov 2, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·H ChambostUNKNOWN for FranceCoag Network group
Apr 2, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·M SteeleL Ford-Jones
Apr 3, 2014·Transfusion·Jonathan A HughesSusan A Galel
Feb 12, 2000·Transfusion Medicine Reviews·L C Richardson, B L Evatt
Mar 10, 2001·Clinics in Liver Disease·A Regev, E R Schiff
May 12, 2000·Hematology/oncology Clinics of North America·M Radosevich
Aug 25, 2004·Clinics in Laboratory Medicine·Eberhard W Fiebig, Michael P Busch
Aug 31, 2000·Biologicals : Journal of the International Association of Biological Standardization·A JohnstonE Uren
Sep 24, 2016·Virus Genes·Andrea HettmannMária Takács

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