PMID: 7515142Apr 1, 1994Paper

Hepatitis B and C virus infection as risk factors for liver cirrhosis and cirrhotic hepatocellular carcinoma: a case-control study

Liver
J F TsaiJ H Tsai

Abstract

To investigate whether hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are risk factors for liver cirrhosis and hepatocellular carcinoma (HCC), a case-control study of 102 cirrhotic HCC patients, 102 sex-matched and age-matched patients with liver cirrhosis, and 102 matched patients with non-hepatic disease controls was performed. The prevalences of hepatitis B surface antigen (HBsAg) and antibody to HCV (anti-HCV) in HCC (70.5%, 39.2%) and liver cirrhosis (74.5%, 27.4%) were higher than controls (16.6%, 10.5%) (P = 0.0001). In HBsAg-negative patients, the prevalence of anti-HCV in cirrhotic HCC (66.6%) and liver cirrhosis (46.1%) was higher than in controls (10.5%; P = 0.0001). There was no such difference in HBsAg-positive patients. Multivariate analysis revealed that both HBsAg and anti-HCV were important risk factors for HCC (odds ratio, 6.52 and 4.59, respectively) and liver cirrhosis (odds ratio, 4.22 and 2.29, respectively). There was no difference in odds ratio when HCC and liver cirrhosis were compared. Our result implies that both HBV and HCV are independent risk factors for cirrhotic HCC and liver cirrhosis in Taiwan.

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Citations

Nov 3, 2010·Molecular and Cellular Biochemistry·Hikmet AkkızYakup Ülger
May 29, 2000·Journal of Gastroenterology and Hepatology·Z Y LinW Y Chang
Apr 22, 2005·Scandinavian Journal of Gastroenterology·J F TsaiC Y Dai
Jul 10, 2007·The Korean Journal of Internal Medicine·Soon Woo NamYoung Suk Lee
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G Corrao, S Aricò
Dec 6, 2008·Environmental Health Perspectives·Mark H KuniholmGregory D Kirk
May 1, 1995·Journal of Medical Virology·J F TsaiJ H Tsai
Jul 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T I HuoS D Lee
Dec 11, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Eric A EngelsJames J Goedert
Apr 15, 2021·Environmental Science and Pollution Research International·Mabrouk Attia Abd EldaimHebatalla Nashaat Elsharkawy

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