PMID: 7539829Feb 1, 1995Paper

Hepatitis B and D genomes in hepatitis B surface antigen negative patients with chronic hepatitis C

Journal of Medical Virology
S GonzálezV Carreño

Abstract

Hepatitis B and hepatitis D viral genomes were tested by nested polymerase chain reaction in the serum and liver of 69 hepatitis B surface antigen (HBsAg) negative, anti-hepatitis C virus (HCV) positive patients (47 with HCV RNA and 22 without HCV RNA). Serum hepatitis B virus (HBV) DNA-was detected in 49% of the patients with HCV-RNA and in 64% of those without HCV-RNA. Furthermore, intrahepatic HBV-DNA was found in four of five (80%) of the biopsies analysed. Delta genome was found in 72% and 73%, respectively, of the anti-HCV positive patients with or without HCV-RNA. In addition, intrahepatic delta virus genome was detected in another four liver biopsies studied. In the group of patients with HCV-RNA, the simultaneous presence of hepatitis B and D genomes was statistically higher in transfused patients than in drug addicts, or in those with an unknown infection route (P < 0.001). These results show a high percentage of B and D genomes in HBsAg negative patients with anti-HCV, irrespective of the presence or absence of the HCV genome. However, the clinical implications of this finding should be examined in future studies.

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Citations

Feb 14, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Paolo FabrisGeoffrey Dusheiko
Apr 1, 1997·Pathology International·T UchidaH Shinzawa
Oct 2, 2009·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Peiman HabibollahiSeyed M Alavian
May 4, 2004·Journal of Medical Virology·Luisa Fernanda MariscalVicente Carreño
Apr 14, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J S F PereiraF L Gonçales Júnior
Jun 26, 2002·Journal of Viral Hepatitis·Ke-Qin Hu
Jun 10, 2003·Journal of Medical Virology·Elena Rodríguez-IñigoVicente Carreño
Oct 1, 2013·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jae Young Jang, Eui Ju Park
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C-K HuiT L Wright
Feb 12, 2008·Reviews in Medical Virology·Vicente CarreñoJuan Antonio Quiroga

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