Abstract
Hepatitis B and hepatitis D viral genomes were tested by nested polymerase chain reaction in the serum and liver of 69 hepatitis B surface antigen (HBsAg) negative, anti-hepatitis C virus (HCV) positive patients (47 with HCV RNA and 22 without HCV RNA). Serum hepatitis B virus (HBV) DNA-was detected in 49% of the patients with HCV-RNA and in 64% of those without HCV-RNA. Furthermore, intrahepatic HBV-DNA was found in four of five (80%) of the biopsies analysed. Delta genome was found in 72% and 73%, respectively, of the anti-HCV positive patients with or without HCV-RNA. In addition, intrahepatic delta virus genome was detected in another four liver biopsies studied. In the group of patients with HCV-RNA, the simultaneous presence of hepatitis B and D genomes was statistically higher in transfused patients than in drug addicts, or in those with an unknown infection route (P < 0.001). These results show a high percentage of B and D genomes in HBsAg negative patients with anti-HCV, irrespective of the presence or absence of the HCV genome. However, the clinical implications of this finding should be examined in future studies.
References
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Aug 1, 1992·The Journal of Infectious Diseases·M ShindoS M Feinstone
Jul 1, 1992·Journal of Virological Methods·I CastilloV Carreño
Sep 1, 1992·Journal of Hepatology·C PorchonC Bréchot
Nov 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T MitsuiS Mishiro
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J H HanM Houghton
Jan 1, 1991·Digestion·I CastilloV Carreño
Dec 1, 1991·Gastroenterology·A OttobrelliA Geubel
Jun 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T J LiangJ R Wands
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T MiyamuraG Kuo
Aug 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T J LiangJ R Wands
Nov 1, 1990·Journal of Hepatology·A MadejónV Carreño
Jul 1, 1990·Journal of Hepatology·A L ZignegoH Bismuth
Apr 21, 1989·Science·G KuoC E Stevens
Nov 30, 1989·The New England Journal of Medicine·H J AlterG Kuo
Apr 21, 1989·Science·Q L ChooM Houghton
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S KanekoR H Purcell
Apr 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W S Mason, J M Taylor
May 18, 1989·Nature·S Kwok, R Higuchi
Oct 9, 1986·Nature·K S WangM Houghton
Jan 1, 1982·Journal of Medical Virology·M BerningerJ L Gerin
Nov 1, 1993·Gastroenterology·P PontissoA Alberti
Jan 1, 1993·Journal of Hepatology·D SamuelJ P Benhamou
Apr 1, 1993·Histopathology·R ColombariP J Scheuer
Citations
Aug 1, 1997·Journal of Medical Virology·T UchidaS Mima
Aug 14, 1999·Journal of Medical Virology·R FukudaY Kinoshita
Feb 15, 2001·Journal of Medical Virology·R FukudaY Kinoshita
Nov 30, 2000·Journal of Hepatology·L Kazemi-ShiraziC Müller
Dec 5, 1998·Free Radical Biology & Medicine·T MatsuoH Kamada
Feb 14, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Paolo FabrisGeoffrey Dusheiko
Apr 1, 1997·Pathology International·T UchidaH Shinzawa
Nov 25, 2005·Journal of Virology·E Rodríguez-IñigoV Carreño
Oct 2, 2009·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Peiman HabibollahiSeyed M Alavian
May 4, 2004·Journal of Medical Virology·Luisa Fernanda MariscalVicente Carreño
Sep 26, 2003·Clinics in Liver Disease·David E Kaplan, K Rajender Reddy
Apr 14, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J S F PereiraF L Gonçales Júnior
Jun 26, 2002·Journal of Viral Hepatitis·Ke-Qin Hu
Jun 10, 2003·Journal of Medical Virology·Elena Rodríguez-IñigoVicente Carreño
Oct 1, 2013·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jae Young Jang, Eui Ju Park
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C-K HuiT L Wright
Feb 12, 2008·Reviews in Medical Virology·Vicente CarreñoJuan Antonio Quiroga