Hepatitis B and hepatitis C virus infection and outcome of hemodialysis and kidney transplant patients

Renal Failure
Visnja LezaicDjukanovic Ljubica

Abstract

A comparison of the outcome of hepatitis virus-positive and -negative kidney transplant and hemodialysis patients was the aim of this investigation. The study involved 384 kidney transplant patients (67 HBsAg positive, 39 anti-HCV positive, 278 hepatitis negative), transplanted between 1987 and 2001, and 403 hemodialysis patients (128 HBsAg positive, 83 anti-HCV positive, 192 hepatitis negative) who had started hemodialysis and were referred to the kidney transplant waiting list during the same period. Hemodialysis patients were older than transplant patients. Comparison of the groups' survival rates, adjusted for patient age, showed that all kidney transplant patients survived longer than hemodialysis patients (p < 0.001). HBV infection had a negative impact on patient survival, especially in hemodialysis patients. HCV infection did not have a significant influence on patient survival. Cardiovascular disease was the main cause of death of all hemodialysis- and hepatitis-negative transplant patients. Liver failure was one of the leading causes of death in HBV-positive transplant patients. Mortality risk was higher for older patients, HBV-positive and -negative hemodialysis patients. Kidney transplantation offers longer survival...Continue Reading

References

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Citations

Feb 4, 2010·Clinics in Liver Disease·Fabrizio Fabrizi, Paul Martin
Sep 3, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M TonelliJ Gill
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J LevitskyUNKNOWN AST Infectious Diseases Community of Practice
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J LevitskyUNKNOWN AST Infectious Diseases Community of Practice
Oct 6, 2012·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Clarke Brian Blackadar

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