PMID: 7537942Apr 1, 1995Paper

Hepatitis B, C, and D virus infections in patients with chronic hepatitis, cirrhosis, and hepatocellular carcinoma: a comparative study in Niger

The American Journal of Tropical Medicine and Hygiene
A CénacA Warter

Abstract

Eighty-nine Sahelian African patients with chronic active hepatitis (CAH) (14), cirrhosis (49), hepatocellular carcinoma (HCC) (26), and 47 controls were tested for hepatitis B virus (HBV, hepatitis B surface antigen [HBsAg]) and hepatitis D virus (HDV, anti-HDV antibody). Seventy-three percent of the patients were positive for HBsAg versus 29.8% of the controls (P < 0.0001). With anti-HDV test, 55.0% of the patients were positive versus 17.0% of the controls (P < 0.0001). To assess the prevalence of antibody to hepatitis C virus (HCV), we used an enzyme-linked immunosorbent assay for screening (anti-HCV2): 19.1% of the patients were positive versus 6.4% of the controls (P < 0.05). An association between HBsAg and anti-HDV-positive test results was found in 46.1% of the patients versus 6.4% of the controls (P < 0.0001). A combination of HBsAg and anti-HCV2-positive test results was found in 13.5% of the patients versus 2.2% of the controls (P < 0.05). Anti-HDV and anti-HCV2 test results were positive in 13.5% of the patients versus 2.2% of the controls (P < 0.05). Triple-positive test results (HBsAg, anti-HDV, and anti-HCV2) were found in 11.2% of the patients but in none of the controls (P < 0.025). Triple-negative test result...Continue Reading

Citations

Oct 1, 1998·Tropical Medicine & International Health : TM & IH·W C MillerG J Lallinger
Apr 29, 2015·World Journal of Hepatology·Zaigham AbbasLubna Shazi
Oct 23, 2010·Expert Review of Molecular Diagnostics·Perumal Vivekanandan, Om Vir Singh
Nov 9, 2016·BMC Infectious Diseases·Marie Atsama AmougouRichard Njouom
Feb 10, 2018·Annals of Occupational and Environmental Medicine·Hogil KimInah Kim
Feb 10, 1998·International Journal of Cancer. Journal International Du Cancer·F DonatoM Puoti
Jan 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·A J Hall
Jul 6, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A LonardoP Loria

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