PMID: 1204961Jan 1, 1975Paper

Hepatitis B core antigen in the immunosuppressed chimpanzee

Developments in Biological Standardization
S Wilson, L M Logan

Abstract

Two chimpanzees with low levels of anti-HBs developed increased antibody titres but showed no antigenemia after i.v. administration of 10 ml infective chimpanzee serum. Treatment of a chimpanzee (also possessing anti-HBs) i.m. with Cyclophosphamide plus Prednisolone for 3 weeks starting 2 days before the challenge with infective serum resulted in detectable circulating HBsAg by day 67. By day 95, the HBsAg concentration had increased to 17 times a human Ag reference plasma and low titres of anti-HBc were also present, but liver enzyme levels did not become abnormal until day 107. Since the circulating HBsAg concentration decreased gradually to 2 times the reference plasma by day 168, the animal was again immunosuppressed using oral Prednisolone alone for 7 weeks and then sacrificed. The liver yielded useful quantities of purified HBcAg while the plasma was an excellent source of Dane particles and HBsAg (41 X human reference plasma). This success could not be reproduced in 4 immunosuppressed cynomolgus monkeys. Our studies, therefore, demonstrate the value of the immunosuppressed high-order primate in the initiation and modulation of hepatitis B.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
F TsudaM Mayumi
Canadian Medical Association Journal
L Spence, M Fauvel
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
K H ChauL R Overby
© 2022 Meta ULC. All rights reserved