Hepatitis B core-related antigen levels are associated with response to entecavir and peginterferon add-on therapy in hepatitis B e antigen-positive chronic hepatitis B patients

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
M J H van CampenhoutHarry L A Janssen

Abstract

Hepatitis B core-related antigen (HBcrAg), a new serum marker, may be useful in monitoring chronic hepatitis B infection. HBcrAg was measured in 175 hepatitis B e antigen-positive patients treated with entecavir (ETV) with or without peginterferon (PEG-IFN) add-on therapy. Decline in HBcrAg was stronger in patients with vs. without combined response (ETV: -3.22 vs. -1.71 log U/mL, p <0.001; PEG-IFN add-on: -3.16 vs. -1.83 IU/mL, p <0.001) and in patients with vs. without hepatitis B surface antigen (HBsAg) response (ETV: -2.60 vs. -1.74 log U/mL, p <0.001; PEG-IFN add-on: -2.38 vs. -2.15 log U/mL, p = 0.31). HBcrAg was associated with combined response (adjusted odds ratio 0.3, 95% confidence interval 0.2-0.5, p <0.001), but was not superior to quantitative HBsAg (qHBsAg).

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Citations

Aug 23, 2016·Current Treatment Options in Infectious Diseases·Carla OsiowyAnton Andonov
May 29, 2019·Journal of Viral Hepatitis·Margo J H van CampenhoutBettina E Hansen
Nov 9, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ivana CareyKosh Agarwal
Nov 25, 2017·Frontiers of Medicine·Shuye ZhangZheng Zhang
Jul 10, 2019·Antiviral Research·Caroline CharreCaroline Scholtès
Sep 26, 2021·Hepatology Communications·Lisa SandmannUNKNOWN HIDIT-II Study Group

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