Hepatitis B e antigen in sera from individuals infected with hepatitis B virus of genotype G

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Hideaki KatoMasashi Mizokami

Abstract

Hepatitis B virus (HBV) genotype G (HBV/G) was detected in sera from four individuals by polymerase chain reaction with hemi-nested primers deduced from an insertion of 36 nt in the core gene that is specific for this genotype. Despite two stop codons in the precore region characteristic of HBV/G, all patients were positive for hepatitis B e antigen (HBeAg) in serum. When 10 HBV clones were propagated from one patient, and sequenced within precore region and a section of the core gene, 6 clones were HBV/G while 2 were genotype A (HBV/A); a recombination between HBV/G and HBV/A occurred in the remaining 2 clones. Mixed infection of HBV/G and HBV/A, as well as the recombination, was demonstrated in the sequence of preS1 and preS2 regions also. Coinfection with HBV/G and HBV/A was demonstrated in the other three patients, and their recombination in two patients. Ten HBV clones were propagated from one patient at two time points separated by 1 year. Clones of HBV/A, HBV/G and their recombination were found in 9 : 1 : 0 when the patient was positive for HBeAg, while the proportion shifted to 0 : 8 : 2 after the patient seroconverted to anti-HBe. In conclusion, HBV/G is frequently found as a coinfection with HBV/A. This coinfection w...Continue Reading

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Citations

Nov 30, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Robério A A Pondé
Nov 23, 2011·Current Gastroenterology Reports·Sudeep Tanwar, Geoffrey Dusheiko
Jun 1, 2011·Indian Journal of Virology : an Official Organ of Indian Virological Society·Ajay KumarBalesh Kumar Tiwari
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Dec 17, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Oliver KirschbergStephan Schaefer
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chi-Jen Chu, Anna S F Lok
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