Hepatitis B immunisation for newborn infants of hepatitis B surface antigen-positive mothers

The Cochrane Database of Systematic Reviews
C Y LeeC Gluud

Abstract

Hepatitis B vaccine and hepatitis B immunoglobulin are considered for newborn infants of HBsAg-positive mothers to prevent hepatitis B infection. To assess the beneficial and harmful effects of hepatitis B vaccines and hepatitis B immunoglobulin in newborn infants of HBsAg-positive mothers. Trials were identified through The Cochrane Neonatal Group Controlled Trials Register, The Cochrane Hepato-Biliary Group Controlled Trials Register, The Cochrane Central Register of Controlled Trials in The Cochrane Library, MEDLINE, and EMBASE (until February 2004), authors of trials, and pharmaceutical companies. Randomised clinical trials comparing: plasma-derived vaccine (PDV) or recombinant vaccine (RV) versus no intervention, placebo, or other active vaccines; hepatitis B immunoglobulin versus no intervention, placebo, or other control immunoglobulin; as well as PDV or RV plus hepatitis B immunoglobulin versus no intervention, placebo, or other control vaccines or immunoglobulin. Outcomes are assessed at maximal follow-up. The primary outcome measure was hepatitis B occurrence, based on a blood specimen positive for HBsAg, HBeAg, or antibody to hepatitis B core antigen (anti-HBc). Binary outcomes are reported as relative risks (RR) wit...Continue Reading

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Citations

Mar 12, 2013·Archives of Disease in Childhood·Tom A YatesMatthew D Snape
Jun 10, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kevin PottieUNKNOWN coauthors of the Canadian Collaboration for Immigrant and Refugee Health
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Feb 12, 2017·The Cochrane Database of Systematic Reviews·Ahizechukwu C EkeJiao Liu
Apr 15, 2011·The Cochrane Database of Systematic Reviews·Yun XiaChristian Gluud
May 2, 2013·The Cochrane Database of Systematic Reviews·Yun XiaChristian Gluud
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