Hepatitis B immunoglobulin prophylaxis after liver transplantation: experience in a tertiary transplant centre

Journal of Clinical and Experimental Hepatology
Joy VargheseMohamed Rela

Abstract

Prophylaxis with hepatitis B immunoglobulin (HBIG) and nucleoside analogs can prevent hepatitis B virus (HBV) recurrence after liver transplant (LT). To determine the efficacy and cost of maintaining immunoprophylaxis with HBIG and hyperimmune plasma (HIP) for 6 months after LT. The study included 22 HBV related LT recipients who were on entecavir and either HBIG or HIP for 6 months. Post transplant HBIG or HIP dose and cost incurred towards prophylaxis were noted. The cost of 200 IU of HBIG at the time of study was Rs 8250/- (US Dollars 135) and that of 2000 IU of HIP was Rs 8000/- (USD 130.7). The loading and maintenance costs at end of 6 months were compared between the two groups. Response to HBIG and HIP was assessed by checking for HBsAg reactivity, anti HBs titer response and HBV DNA viral load. Median and range, Kruskal Wallis (KW) sign rank Sum Test and Correlation Coefficient (r2) was used for analysis. Thirteen recipients received HBIG and 9 recipients HIP. The anti HBs response to HIP was significantly high compared to HBIG (KW Sign rank Sum test P < 0.05); titers remained high until the study period. Between 8 and 30 days, the titer achieved by both HBIG and HIP was similar (KW Sign rank Sum test not significant). ...Continue Reading

References

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Apr 25, 2014·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Joy VargheseMohamed Rela

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Citations

Feb 24, 2016·Journal of Clinical and Experimental Hepatology·Sanjay NagralAabha Nagral
Sep 25, 2017·Journal of Clinical and Translational Hepatology·Gautam Ray

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