Hepatitis B immunoprophylaxis failure and the presence of hepatitis B surface gene mutants in the affected children

Journal of Medical Virology
Le Ye LeeGuan Huei Lee

Abstract

Hepatitis B virus (HBV) infection is usually vertically transmitted from the mother to child during birth in Asian countries. Despite immunization, immunoprophylaxis failure is well-documented. The aim of the study was to study immunoprophylaxis failure rate in the cohort of infants delivered by chronic HBV-infected mothers and to determine risk factors for failure. This was an observational study involving chronic hepatitis B infected mothers seen at a tertiary care center in Singapore between June 2009 and December 2013. Infants born to these mothers were recruited after they had completed the recommended vaccination schedule. Serological testing for the children was performed 3 months after completion of the last dose of vaccine. HBV surface gene sequencing was carried out if HBV DNA was detectable in the children. Among the 161 mothers enrolled, most were HBeAg negative. HBeAg positive mothers were younger and had a significantly higher viral load (6.5 log) as compared to HBeAg negative mothers (1.35 log) (P < 0.001). Four children (2.6%) were found to have immunoprophylaxis failure. Two occurred in children delivered by mothers with extremely high viral load of more than 5 × 10(7)  IU/ml. HBV surface gene mutations were de...Continue Reading

References

Jul 18, 2003·The Pediatric Infectious Disease Journal·Yao-Jong YangMei-Hwei Chang
Nov 23, 2006·European Journal of Pediatrics·Yun-Mi SongWon Soon Park
Sep 4, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mira El ChaarJean Pierre Allain
Jan 9, 2013·Virology Journal·Yang DingXiaoguang Dou
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Citations

Jan 12, 2016·Expert Review of Gastroenterology & Hepatology·Maria Grazia Clemente, Pietro Vajro
Apr 1, 2016·The Journal of General Virology·Eleanor A PowellJason T Blackard
May 5, 2017·Viruses·Patrick T F KennedyWilliam S Mason
Feb 24, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hong-Lin ChenGang Qin
Apr 25, 2018·The Journal of Infectious Diseases·Shoshanna MaySamreen Ijaz
Mar 5, 2020·The Journal of Obstetrics and Gynaecology Research·Pınar Ergen, Fatma Yilmaz Karadağ
Jun 11, 2015·Emerging Microbes & Infections·Zixiong LiGuangwen Cao

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