PMID: 6163084Mar 5, 1981Paper

Hepatitis B polypeptide vaccine preparation in micelle form

Nature
J SkellyA J Zuckerman

Abstract

The immunoprophylaxis of hepatitis B is hampered by the lack of a technique for growing hepatitis B virus (HBV) in tissue culture. Plasma from persistently infected individuals, one source of viral antigen, contains characteristic 22-nm spherical particles which share a common antigen (the hepatitis B surface antigen or HBsAg) with the outer envelope of the 42-nm double-shelled DNA virus. Highly purified inactivated 22-nm particles have been shown to be safe and to confer protective immunity against HBV in a recent large-scale clinical trial. We have already described the extraction from the particles of a complex of two proteins which are antigenic determinants of HBV--the polypeptide with molecular weight (MW) between 22,000 and 24,000 (called p23) and the glycosylated polypeptide (called gp28) with MW in the range 26,000--29,000 which is thought to be the glycosylated form of p23. We now report the preparation from this complex of water-soluble protein micelles which may be a suitable basis for a second-generation hepatitis B vaccine.

References

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Citations

Apr 1, 1981·Springer Seminars in Immunopathology·C R Howard
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·A J Zuckerman
Jul 1, 1981·Journal of Virological Methods·J SkellyA J Zuckerman
Apr 1, 1982·Journal of Virological Methods·P YoungA J Zuckerman
Sep 1, 1990·Baillière's Clinical Gastroenterology·A J Zuckerman
Nov 27, 1982·Lancet
Sep 1, 1984·The Journal of General Virology·N KalkkinenR F Pettersson
Mar 16, 2006·Journal of Virology·Isabelle DesombereGeert Leroux-Roels
Mar 6, 1982·British Medical Journal·A J Zuckerman
Feb 16, 1985·British Medical Journal·A J Zuckerman
Jul 9, 1988·BMJ : British Medical Journal·A J Zuckerman
Jul 1, 1986·Gut·E A Fagan, R Williams
Jan 14, 1982·Nature·A J Zuckerman
Oct 10, 1985·Nature·P TiollaisA Dejean
Feb 7, 1998·Journal of Pharmaceutical Sciences·J S TungG Mark
Feb 15, 1995·Biochimica Et Biophysica Acta·J Gómez-GutiérrezF Gavilanes
Jul 1, 1986·Journal of Medical Virology·F B HollingerJ L Melnick
Oct 1, 1987·Journal of Medical Virology·K MurrayH Schellekens
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E Celis, T W Chang
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·A J Zuckerman

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