Hepatitis B seroprevalence among 5 to 6 years old children in the Philippines born prior to routine hepatitis B vaccination at birth

Human Vaccines & Immunotherapeutics
Anna Lena LopezMaria Joyce Ducusin

Abstract

To assess the prevalence of hepatitis B in the Philippines, we conducted a cross-sectional study among 5 to 6 year old children born in 2007-2008, when the birth dose started to be implemented in the country. The study was conducted from 25 July to 22 October 2013 in 24 provinces and used a 3-stage cluster design and probability-proportional to size sampling. Blood was obtained and sera were tested for hepatitis B surface antigen (HBsAg). The survey included 2,769 children, of whom 26% received a timely birth dose (within 24 hours of birth) and 89% received 3 doses of the hepatitis B vaccine. Due to problems in the initial testing algorithm, only 2,407 sera were available for HBsAg testing, 20 (weighted%, 0.86%) were HBsAg positive. By immunization card and recall, among HBsAg positive children, 2 (weighted%, 20%) received a timely birth dose while 17 (weighted%, 85%) received 3 doses of the hepatitis B vaccine. The seroprevalence of HBsAg that we detected was lower than expected. However, there were several limitations in the field and in the laboratory that may have affected the representativeness of the results. Follow up studies need to be conducted to validate these results.

References

Oct 27, 2005·International Journal of Epidemiology·Susan T GoldsteinHarold S Margolis
May 15, 2013·World Journal of Hepatology·Stephen N WongMarilyn O Arguillas
Sep 18, 2016·The Lancet Infectious Diseases·Shevanthi NayagamTimothy B Hallett

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Methods Mentioned

BETA
ELISA
blood draw

Software Mentioned

SAS
PhilHealth
SUDAAN
Stata

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