Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg+/HBeAg- mothers.

Cellular & Molecular Immunology
Lemonica KoumbiVassiliki Papaevangelou

Abstract

Vertically transmitted hepatitis B virus (HBV) usually causes chronic infection. While combined active-passive immunoprophylaxis in neonates of hepatitis B surface antigen-positive (HBsAg(+)) mothers at birth prevents vertical transmission, it is not yet clear whether neonates encounter the virus or its products in the absence of hepatitis B e antigen (HBeAg). This study was undertaken to investigate HBV antigen-specific T-cell responses in vaccinated neonates of HBsAg(+)/HBeAg(-) mothers. Blood was collected from 46 HBsAg(+) mothers and their neonates (subjects) as well as 24 age-matched controls. All neonates of HBsAg(+) mothers received appropriate immunoprophylaxis, and HBsAg and hepatitis B surface antibody (anti-HBs) antibody titers were determined after completion of the vaccination course. Peripheral blood mononuclear cells (PBMCs) from infants at birth, 1 and 6 months of age were stimulated with recombinant HBsAg, hepatitis B core antigen (HBcAg) and mitogen, and interferon (IFN)-γ concentrations were determined by ELISA. HBsAg-induced production of IL-2, IL-5, IL-6 and IL-10 was assessed using a cytometric bead array kit on cells from 6-month-old neonates post-vaccination. All neonates were HBsAg(-) and responded to v...Continue Reading

References

Apr 10, 1975·The New England Journal of Medicine·C E StevensW C Lee
Jul 1, 1992·Indian Journal of Pediatrics·S AkhterS Begum
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M R BrunettoH Will
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D R MilichA McLachlan
Apr 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K C Hyams
May 15, 2002·Journal of Virological Methods·D ParaskevisA Hatzakis
Dec 20, 2002·Pathologie-biologie·S Ranger-RogezF Denis
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David Milich, T Jake Liang
May 27, 2004·World Journal of Gastroenterology : WJG·Ruo-Bing LiYu Wang
Mar 6, 2007·Seminars in Fetal & Neonatal Medicine·Mei-Hwei Chang
Aug 19, 2008·Autoimmunity Reviews·Patrizia PontissoAngelo Gatta
May 14, 2010·Clinical and Vaccine Immunology : CVI·Lemonica J KoumbiVassiliki Papaevangelou

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Citations

Sep 2, 2014·Cellular & Molecular Immunology·Antonio Bertoletti, Patrick T Kennedy
Oct 9, 2014·Frontiers in Immunology·Antonio Bertoletti, Michelle Hong
May 23, 2018·Biotechnology & Genetic Engineering Reviews·Shivali S Joshi, Carla S Coffin
Sep 14, 2017·Seminars in Immunopathology·Dania Zhivaki, Richard Lo-Man
Aug 25, 2012·Nature Reviews. Immunology·Andrew J PrendergastPhilip J R Goulder
Dec 12, 2013·Clinical and Experimental Immunology·L AfranS L Rowland-Jones
Jul 10, 2012·European Journal of Gastroenterology & Hepatology·Virginia ChatzidakiEmmanouil Galanakis
Jul 8, 2017·Seminars in Immunopathology·Michelle Hong, Antonio Bertoletti
Feb 7, 2020·Hepatology Communications·Shivali S Joshi, Carla S Coffin
Apr 8, 2017·Scandinavian Journal of Immunology·A K VyasN Trehanpati
May 18, 2021·Frontiers in Pediatrics·Bianca CinicolaMarzia Duse

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