Hepatitis B surface antigen, core-related antigen and HBV RNA: Predicting clinical relapse after NA therapy discontinuation.

Liver International : Official Journal of the International Association for the Study of the Liver
Apichat KaewdechTeerha Piratvisuth

Abstract

The safe discontinuation of nucleos(t)ide analogue therapy remains challenging in chronic hepatitis B. We investigated the potential role of quantitative hepatitis B surface antigen, hepatitis B core-related antigen and hepatitis B virus RNA at the end of treatment in predicting off-therapy relapse. Patients who fulfilled the stopping criteria of the Asian Pacific Association for the Study of the Liver guideline were enrolled. Virological relapse was defined as hepatitis B virus DNA level greater than 2000 IU/mL, and clinical relapse was defined as virological relapse plus alanine aminotransferase level of more than twice the upper limit of normal. Ninety-two patients participated. The combination of end-of-treatment hepatitis B core-related antigen and hepatitis B virus RNA levels was most predictive of clinical relapse. Multivariate analysis revealed that end-of-treatment hepatitis B core-related antigen and hepatitis B virus RNA were independently associated with clinical relapse. During follow-up, no patients with undetectable hepatitis B core-related antigen (<3.0 log10 U/mL) and hepatitis B virusRNA (<2.0 log10 copies/mL) at end of treatment developed clinical relapse, in comparison with 22.9% and 62.5% patients with dete...Continue Reading

References

Mar 12, 2004·The New England Journal of Medicine·Don Ganem, Alfred M Prince
Jun 23, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Akihiro MatsumotoKendo Kiyosawa
Nov 23, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Akihiro MatsumotoHiromitsu Kumada
Apr 23, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Fabien ZoulimFanny Lebossé
Dec 7, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Sadahisa OkuharaEiji Tanaka
Aug 19, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Florian van BömmelAnke Edelmann
Nov 14, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A TerraultUNKNOWN American Association for the Study of Liver Diseases
Nov 14, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S F LokKhaled Mohammed
Jan 5, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Rajneesh KumarFabien Zoulim
Apr 23, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·George PapatheodoridisJörg Petersen
Apr 22, 2017·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Jul 25, 2017·Journal of Hepatology·Thomas BergUNKNOWN FINITE CHB study investigators [First investigation in stopping TDF treatment after long-term virological suppression in HBe
Nov 7, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wen-Juei JengYun-Fan Liaw
Feb 11, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Florian van Bömmel, Thomas Berg
May 2, 2018·JAMA : the Journal of the American Medical Association·Lydia S Y TangShyam Kottilil
May 10, 2018·The Journal of Infectious Diseases·Florian van BömmelStephan Böhm
Oct 27, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shi LiuHaitao Guo
Dec 19, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jiaye LiuAiqiang Xu
Feb 26, 2019·Journal of Viral Hepatitis·Margarita Papatheodoridi, George Papatheodoridis
Jul 31, 2019·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rong FanUNKNOWN Chronic Hepatitis B Study Consortium
Nov 9, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ivana CareyKosh Agarwal
Dec 18, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Grace L-H WongVincent W-S Wong

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Citations

Apr 4, 2021·Journal of Gastroenterology and Hepatology·Aunchalee JaroenlapnopparatPisit Tangkijvanich
Sep 11, 2021·Alimentary Pharmacology & Therapeutics·Malte H Wehmeyer, Julian Schulze Zur Wiesch

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