Hepatitis B: treatment choice and monitoring for response and resistance

Expert Review of Gastroenterology & Hepatology
Sze-Hang Kevin LiuMan-Fung Yuen

Abstract

Despite effective preventive primary prevention with vaccination, many people remain infected with hepatitis B virus (HBV) and suffer from its complications. Effective treatments such as interferon-based regimens and oral nucleoside/nucleotides have been developed over the last 30 years, but they are not perfect. Each of the treatments has its own merits, but none can eradicate HBV from the host. As a result, regular monitoring of the response during treatment and after treatment is required. The choice and monitoring of selected treatments, new potential therapeutic agents, and treatment options for drug resistance are discussed in this review.

References

Oct 21, 1998·The Journal of Infectious Diseases·A R MarquesJ H Hoofnagle
Feb 15, 1965·JAMA : the Journal of the American Medical Association·B S BLUMBERGS VISNICH
Jun 9, 2004·Annals of Medicine·San-Lin YouChien-Jen Chen
Sep 17, 2004·The New England Journal of Medicine·Patrick MarcellinUNKNOWN Peginterferon Alfa-2a HBeAg-Negative Chronic Hepatitis B Study Group
Jan 11, 2005·Lancet·Harry L A JanssenUNKNOWN Rotterdam Foundation for Liver Research
Jul 1, 2005·The New England Journal of Medicine·George K K LauUNKNOWN Peginterferon Alfa-2a HBeAg-Positive Chronic Hepatitis B Study Group
Jul 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stefan F WielandFrancis V Chisari
Jan 5, 2006·JAMA : the Journal of the American Medical Association·Chien-Jen ChenUNKNOWN REVEAL-HBV Study Group
Mar 15, 2006·Gastroenterology·Uchenna H IloejeUNKNOWN Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer-In HBV (the REVEAL-HBV) Study Group
Sep 29, 2006·Journal of Molecular Recognition : JMR·Stephen J Stray, Adam Zlotnick
Feb 23, 2007·Journal of Virology·David H NguyenJianming Hu
Jun 29, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S LokUNKNOWN Hepatitis B Virus Drug Resistance Working Group
Jan 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael W FriedMatei Popescu
Mar 12, 2008·Journal of Hepatology·Stéphanie VilletFabien Zoulim
Jun 26, 2008·Nature Reviews. Immunology·Anthony J Sadler, Bryan R G Williams
Dec 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rami MoucariPatrick Marcellin
Feb 26, 2009·Cell·Richard W Carthew, Erik J Sontheimer
Mar 24, 2009·Gastroenterology·Patrick MarcellinUNKNOWN Peginterferon alfa-2a in HBeAg-negative Chronic Hepatitis B Study Group
Mar 28, 2009·The Lancet Infectious Diseases·Man-Fung YuenChing-Lung Lai
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G Ghany, Edward C Doo
Jun 12, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nghi B HaMindie H Nguyen
Aug 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S F Lok, Brian J McMahon
Sep 10, 2009·Gastroenterology·Fabien Zoulim, Stephen Locarnini
Jan 6, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ting-Tsung ChangUchenna Iloeje
Mar 9, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vincent Wai-Sun WongHenry Lik-Yuen Chan
May 13, 2010·The American Journal of Gastroenterology·Vincent RijckborstUNKNOWN PARC Study Group
Aug 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vincent RijckborstHarry L A Janssen
Sep 3, 2010·Alimentary Pharmacology & Therapeutics·G L-H WongH L-Y Chan
Oct 20, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Debika Bhattacharya, Chloe L Thio
Apr 20, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hui JinPei Liu
Oct 4, 2011·The Journal of Antimicrobial Chemotherapy·James FungMan-Fung Yuen
Mar 23, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Apr 18, 2012·Alimentary Pharmacology & Therapeutics·N GaraJ H Hoofnagle
Jul 19, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ching-Lung Lai, Man-Fung Yuen
Dec 6, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tetsuya HosakaHiromitsu Kumada

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Citations

Dec 21, 2017·Terapevticheskiĭ arkhiv·V P ChulanovV V Maleyev
Jun 18, 2019·The Journal of General Virology·Liyuan QianSongdong Meng
May 12, 2019·Genes·Takako Inoue, Yasuhito Tanaka
Oct 9, 2019·The Medical Journal of Australia·Sakhee Kotecha, Trevor J Williams
Nov 25, 2020·Journal of Drug Targeting·Dana ElkhalifaAshraf Khalil
Aug 14, 2021·Revista de gastroenterología de México·F Higuera-de-la-TijeraE Wolpert-Barraza

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