PMID: 11318074Apr 25, 2001Paper

Hepatitis B vaccines: assessment of the seroprotective efficacy of two recombinant DNA vaccines

Clinical Therapeutics
T CoatesV Watson

Abstract

In universal vaccination programs, when there is no postvaccination sero-1 logic assessment of response, there must be confidence that the vaccines used provide a high degree of seroprotection. This parallel analysis of 2 recombinant hepatitis B vaccines (Engerix B and Recombivax/HB-Vax II) was conducted to review the seroprotective efficacy of each vaccine in defined populations. Clinical studies of the 2 vaccines published as manuscripts or conference abstracts in the public domain between January 1986 and April 1999 were identified retrospectively by unrestricted screening of journals through BIOSIS, MEDLINE, and EMBASE and the Internet. Unpublished or internal company data were excluded to maintain impartiality. The studies were reviewed and analyzed. The studies were not assessed for quality other than a judgment of their eligibility for inclusion in the analysis. The primary outcome measure was the proportion of subjects in defined populations who showed an early seroprotective response to currently licensed vaccination schedules. Summary statistical analyses of seroprotective response rates and 95% CIs were calculated for each vaccine for each population. Seroprotective response was defined by an anti-hepatitis B surface...Continue Reading

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Citations

Jan 8, 2004·Journal of Hepatology·Daniel Shouval
Jan 27, 2006·Epidemiology and Infection·J MossongF Schneider
Feb 20, 2013·Nature Reviews. Gastroenterology & Hepatology·Javier P Gisbert, María Chaparro
Jul 23, 2013·Virology Journal·Wolfram H Gerlich
Nov 17, 2012·World Journal of Gastroenterology : WJG·Salvatore LeonardiMario La Rosa
Mar 30, 2013·World Journal of Gastroenterology : WJG·Elisa CarreraElena Garrido
Dec 8, 2011·Digestive Diseases and Sciences·Mustafa Erhan AltunözAyşe Oya Kurdaş Ovünç
Feb 23, 2011·Der Internist·M Cornberg, M P Manns
Apr 6, 2007·Expert Review of Vaccines·Michael Kundi
Mar 26, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Gurkan MertCan Polat Eyigun
Dec 10, 2015·Immunologic Research·Linna YangQian Li
May 27, 2015·The Journal of Pediatrics·H Sonali MagdoKurt R Schumacher
Apr 2, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·M SteeleL Ford-Jones
Nov 11, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·S L CarpenterUNKNOWN Hemophilia Treatment Center Network Investigators
May 11, 2010·Immunological Investigations·Juliana Bessa, Martin F Bachmann
Nov 6, 2012·Journal of Zhejiang University. Science. B·Jing-jing RenLan-juan Li
Mar 1, 2012·Human Vaccines & Immunotherapeutics·Salvatore LeonardiMario La Rosa
Dec 9, 2014·Human Vaccines & Immunotherapeutics·Giovanna ZanoniDino Veneri
Dec 20, 2014·Medical Microbiology and Immunology·Geert Leroux-Roels
Dec 20, 2014·Medical Microbiology and Immunology·Wolfram H Gerlich
May 14, 2016·Human Vaccines & Immunotherapeutics·María Elena Cárdenas-PereaFrancisca Sosa-Jurado
Aug 17, 2016·BMC Infectious Diseases·Chul S HyunSeulgi Lee
Jan 11, 2017·The American Journal of Gastroenterology·Francis A FarrayeSunanda V Kane

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