PMID: 7026400Jan 1, 1981Paper

Hepatitis B viral markers in severe viral hepatitis: influence of steroid therapy

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
H B GreenbergP B Gregory

Abstract

In our double-blind randomized trial of methylprednisolone vs. placebo in severe viral hepatitis, 16 patients with hepatitis B (8 on steroid, 8 on placebo) were followed for at least 4 weeks. Four of the eight patients receiving methylprednisolone eventually died and all patients on placebo survived. Despite marked reduction in serum IgG in steroid-treated patients, the decline in HBsAg titer and disappearance of Dane particle markers was the same in both treatment groups. A nonspecific depression of anti-HBc was noted in patients given steroid. There is no evidence that corticosteroid therapy accelerates viral replication when the acute hepatitis is severe.

References

Apr 21, 1978·JAMA : the Journal of the American Medical Association·R B PollardW S Robinson
Mar 25, 1976·The New England Journal of Medicine·A G RedekerH S Yamahiro
Sep 2, 1976·The New England Journal of Medicine·H B GreenbergT C Merigan
Jul 1, 1975·The American Journal of the Medical Sciences·W S Robinson
Jul 1, 1969·Gut·D V Datta, K J Isselbacher
Apr 1, 1971·The Quarterly Journal of Medicine·G C CookS Sherlock

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Citations

Apr 28, 2009·Infectious Disease Clinics of North America·Lise L Gluud, Christian Gluud
Sep 1, 1984·The American Journal of Medicine·S M de la MonteG W Moore
Aug 17, 2004·Scandinavian Journal of Infectious Diseases·Vasilios Pyrgos, Faheem Younus
Apr 2, 2013·European Journal of Gastroenterology & Hepatology·Bing HeShi-Ming Yang

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