Hepatitis B virus core interacts with the host cell nucleolar protein, nucleophosmin 1.

The Journal of Microbiology
Su Jin LeeGu hung Jung

Abstract

Hepatitis B virus (HBV) genome replication requires the packaging of viral factors (pregenomic RNA and polymerase) as well as host factors, including heat shock proteins and protein kinase C. Previous reports have suggested that there are several unidentified host factors that affect this encapsidation step. In this study, we identified a new host factor, nucleophosmin (B23) that interacts with the HBV core protein 149 (Cpl49). We analyzed this factor using NHS-activated sepharose resin and MALDI-TOF MS. Using the BIAcore analysis system, we were also able to deduce that the B23.1 residues 259-294 were required for the interaction between Cpl49 and B23.1 in vitro.

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Citations

Nov 3, 2014·Annual Review of Virology·Todd M GrecoIleana M Cristea
Dec 15, 2010·Biochemistry Research International·Mikael S Lindström
Mar 29, 2018·Infectious Disorders Drug Targets·Yadira Lobaina, Yasser Perera
Jul 16, 2020·International Journal of Molecular Sciences·Ilaria CelaLuca Federici
Jan 24, 2017·Molecular BioSystems·L M Ogawa, S J Baserga
May 29, 2018·AIDS Research and Human Retroviruses·Jerlisa Ann C ArizalaJohn J Rossi
Sep 1, 2020·Antiviral Research·Senko Tsukuda, Koichi Watashi
Sep 30, 2017·Journal of Proteome Research·Rachy AbrahamEaswaran Sreekumar

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