PMID: 3384275Apr 1, 1988Paper

Hepatitis B virus DNA polymerase activity and hepatitis B e antigen (HBeAg)/anti-HBe status among type B chronic liver diseases

Gastroenterologia Japonica
S KashiwagiM Kaji

Abstract

To investigate the relationship between hepatitis B virus (HBV) replication and chronic liver disease, age-specific prevalences of HBeAg, anti-HBe, and HBV DNA polymerase (DNAP) activity were studied in 295 asymptomatic HBV carriers and 183 patients with B-type chronic liver diseases. DNAP activity decreased with age, and there was no difference in the overall prevalence of DNAP activity between the asymptomatic carriers (27.8%) and the chronic liver disease patients (27.3%). The prevalence of DNAP activity in the 40-and-over age group was significantly higher for the chronic liver disease patients (17.5%) than for the asymptomatic carriers (1.7%). The prevalence of HBeAg in the 40-and-over age group was also significantly higher for the chronic liver disease patients (33.8%) than for the asymptomatic carriers (2.6%). These data suggest that viral replication decreased with age and that viral replication occurring in older persons closely related to chronic liver disease.

References

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Nov 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L L AndresP B Gregory

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Citations

Feb 1, 1990·Gastroenterologia Japonica·J HayashiH Nomura
Apr 1, 1990·Gastroenterologia Japonica·B M GandhiB N Tandon

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