Hepatitis B virus genetic diversity and mutant

The Korean Journal of Hepatology
Hyung Joon Yim

Abstract

Hepatitis B virus (HBV) is a partially double stranded DNA virus with genetic diversity represented by eight genotypes (A to H). Natural course and response to treatment could be affected by HBV genotypes. HBV shows high rates of turn over in the absence of proof-reading ability. As a result, large amounts of quasispecies are produced naturally or antiviral-associated. HBV consists of four open reading frames, namely preS/S gene, precore/core gene, polymerase gene, and X gene. Mutations on preS gene can result in undetectable HBsAg even in case that HBV is replicating. Surface gene mutation leads to decreased binding affinity to anti-HBs, which is associated with a vaccine escape mutant. Precore mutation abolishes HBeAg whereas mutations on basal core promoter gene down-regulate the HBeAg production. Mutations on basal core promoter are associated with increased HBV replication and high incidence of progressive liver diseases such as liver cirrhosis and hepatocellular carcinoma. Mutations on polymerase genes are often induced by antiviral therapy. Emergence of antiviral-resistant mutation is the major cause of treatment failure. Furthermore, existence of prior antiviral-resistant mutations limits the options of subsequent antiv...Continue Reading

References

Jul 1, 1975·The American Journal of the Medical Sciences·G L Bouvier, A Williams
Aug 11, 1990·Lancet·W F CarmanH C Thomas
Aug 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W F CarmanH C Thomas
Jun 13, 1991·The New England Journal of Medicine·T J LiangE Ben-Porath
May 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M OdièvreD Alagille
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·A S LokS Greene
Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U S AkarcaA S Lok
Jan 1, 1995·Intervirology·C R Howard, L M Allison
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H Y HsuD S Chen
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M G GhanyA S Lok
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U Protzer-KnolleG Gerken
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M FriedtS Wirth
Jun 29, 1999·Advances in Virus Research·S GüntherH Will
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M P CooremanW P Paulij
Dec 22, 1999·Journal of Virological Methods·R JardiJ Guardia
Mar 8, 2000·Microbiology and Molecular Biology Reviews : MMBR·C Seeger, W S Mason
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C M HuntL D Condreay
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S LokP Andreone
Mar 7, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L J StuyverR F Schinazi
Mar 15, 2002·The Lancet Infectious Diseases·Maria-Christina Jung, Gerd R Pape
Oct 9, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Joseph Torresi
Dec 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hajime SumiHiromitsu Saisho
Aug 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Birgit RabeMichael Kann

❮ Previous
Next ❯

Citations

Jan 9, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Hyung Joon YimSoon Ho Um
Oct 18, 2013·Clinical and Molecular Hepatology·Hyung Joon Yim, Seong Gyu Hwang
Sep 22, 2016·Infectious Agents and Cancer·Brunel Monic AngoundaJean-Rosaire Ibara
Jun 9, 2015·World Journal of Hepatology·Lemonica Koumbi
Feb 15, 2011·Journal of Agricultural and Food Chemistry·Hong-Yin WuWen-Ling Shih

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Related Papers

Zeitschrift für Gastroenterologie
H E BlumJ W Rasenack
Nature Reviews. Gastroenterology & Hepatology
Watcharasak Chotiyaputta, Anna S F Lok
The Korean Journal of Hepatology
Kwan Sik LeeKorean Association for the Study of the Liver Guideline Committee
© 2021 Meta ULC. All rights reserved