Hepatitis B virus genotype D strains from Estonia share sequence similarity with strains from Siberia and may specify ayw4

Journal of Medical Virology
Tatjana TalloLars O Magnius

Abstract

The genotypes and subtypes of 205 HBV isolates collected during 1989-2002 in Estonia and 14 other regions of the former USSR were determined by sequencing and phylogenetic analysis of the S gene. The in Europe prevailing genotypes, A and D, were also circulating in the whole territory of the former USSR including Estonia and accounted for 18.5 and 81% of the strains, respectively. All genotype A strains specified adw2, and a single genotype C strain specified adrq+. Most genotype D strains specified ayw3 and ayw2, although, three strains from Estonia and Siberia specified ayw4. Due to unique substitutions, Ser122 and Ala127, four strains could not be classified according to the subtype. One strain specifying ayw3 encoded Leu143 and Ala145 and was possibly an immune "escape" mutant. At phylogenetic analysis 93% of the Estonian genotype D strains belonged to a cluster specifying mainly ayw3 and were more similar to isolates from Siberia and the Far-East of Russia than to isolates originating from Central Russia which belonged to another cluster of strains specifying mainly ayw2. This pattern might be explained by part of the Estonian population, has roots east of European Russia, based on linguistic evidence. Eight dominant HBV s...Continue Reading

References

Jan 27, 1975·JAMA : the Journal of the American Medical Association·L O MagniusS Iwarson
Dec 1, 1992·The Journal of General Virology·H NorderL O Magnius
Aug 11, 1990·Lancet·W F CarmanH C Thomas
Jan 1, 1991·Journal of Hepatology·T J HarrisonA J Zuckerman
Jul 1, 1990·Journal of Medical Virology·H NorderL O Magnius
Jan 1, 1987·Annual Review of Biochemistry·D Ganem, H E Varmus
Jun 1, 1971·The Journal of Infectious Diseases·G L Le Bouvier
Dec 1, 1972·The Journal of Infectious Diseases·I GordonA G Redeker
Jan 21, 2000·The Journal of General Virology·L StuyverR Rossau
Jul 19, 2002·The Journal of General Virology·Patricia Arauz-RuizLars O Magnius
Jan 15, 2003·Journal of Medical Virology·Swati S GandheVidya A Arankalle
Aug 26, 2003·Journal of Medical Virology·I G NetesovaS V Netesov

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Citations

Jan 2, 2007·Archives of Virology·K N SzomorM Takács
Nov 6, 2010·Virology Journal·Naila HannachiJalel Boukadida
Jul 14, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Stephan Schaefer
Feb 17, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Fuat KurbanovMasashi Mizokami
Jul 18, 2008·The Journal of General Virology·Tatjana TalloHeléne Norder
Mar 12, 2015·Journal of Medical Virology·Rinat A MaksyutovAleksandr N Kanev
Dec 7, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Gianguglielmo ZehenderMassimo Galli
Apr 1, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C M OlingerC P Muller
Aug 15, 2015·PloS One·Carolina Souza GusattiMaria Lucia Rosa Rossetti
Feb 8, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Krzysztof Piotr Bielawski, Piotr Stalke
Jun 23, 2006·Virus Genes·Krzysztof Piotr BielawskiAnna Jadwiga Podhajska
Jan 22, 2008·Journal of Medical Virology·A Arzu SayinerAylin Sengonul
Nov 22, 2005·Journal of Medical Virology·Kojiro MichitakaMorikazu Onji
Feb 24, 2006·Emerging Infectious Diseases·Paul F Coleman
Nov 18, 2015·World Journal of Gastroenterology : WJG·Rosa ZampinoNicola Coppola
Mar 7, 2020·The Journal of General Virology·Anna L McNaughtonM Azim Ansari
Aug 11, 2009·Central European Journal of Public Health·Gerli PaatKalle Ahi

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