Hepatitis B virus genotypes and G1896A precore mutation in 486 Spanish patients with acute and chronic HBV infection

Journal of Viral Hepatitis
F Rodriguez-FriasJaime Guardia

Abstract

This study aims to determine the prevalence of hepatitis B virus (HBV) genotypes (A-F) and their association with the G1896A precore mutation in 486 patients positive for HBV surface antigen. Genotypes were determined by RFLP and precore mutation by real-time PCR. Genotypes D (48.1%) and A (39.5%) were the most common, followed by F (4.1%) and B, C and E (<1%). The A to D ratio (A:D) was 1.4 in HBeAg+ chronic hepatitis B (CHB), 0.6 in HBeAg- CHB and 1.4 in HBeAg- inactive carriers. Distribution of these genotypes was different between HBeAg+ CHB and HBeAg- CHB (P = 0.02), and between HBeAg- CHB and HBeAg- inactive carriers (P = 0.009). Genotype A was the most prevalent in HBeAg+ CHB with elevated alanine aminotransferase (ALT) (68.6%) and genotype D in HBeAg+ CHB with fluctuating ALT (60.7%). There was a difference in genotype prevalence between chronic and acute infection (P = 0.03). The precore mutant correlated with high levels of HBV-DNA in genotype d HBeAg- CHB. Genotype D is not as highly prevalent in Spanish patients as would be expected in a Mediterranean area. The unequal prevalence of genotypes between acute and chronic infection suggests that genotype A is associated with a higher tendency to cause chronic infection.

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Citations

Jan 20, 2009·World Journal of Gastroenterology : WJG·Rafael Bárcena Marugán, Silvia García Garzón
Nov 14, 2013·World Journal of Gastroenterology : WJG·Francisco Rodriguez-FriasMaria Homs
Nov 1, 2011·Clinics and Research in Hepatology and Gastroenterology·Laure PanassiéPhilippe Colson
Jan 19, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Yan LiuDongping Xu
Jun 15, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Stephen E ConglyCarla S Coffin
Feb 17, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Fuat KurbanovMasashi Mizokami
Aug 3, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Bassem S S GuirgisHassan M E Azzazy
Jun 16, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S C PezzanoV A Mbayed
Mar 6, 2015·PloS One·Carmen L LoureiroFlor H Pujol
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Jul 31, 2007·The American Journal of Gastroenterology·Robert G GishRobert Perrillo
Mar 1, 2013·Emerging Microbes & Infections·Shuping TongYu-Mei Wen

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