Hepatitis B virus genotypes and precore and core mutants in UAE patients.

Virology Journal
Mubarak AlfaresiAdeel Islam

Abstract

Knowledge of the HBV genotype with which a patient is infected is crucial information for a physician to have when planning clinical treatment for that patient. Previous studies have suggested that there are possible differences in the pathogenicity and therapeutic response of different HBV genotypes. However, the prevalence of the various HBV genotypes and Precore and Core mutations is unknown in the UAE. Therefore, we sought to determine the prevalence of the different HBV genotypes in the UAE population. A total of 88 HBsAg-positive patients were included in the study. A method for genotyping and subtyping HBV by partial HBsAg gene sequencing using primers that are complementary to all known genotypes was used. Precore and core region of these viruses were also sequenced in 88 patients.HBV genotype D was the most prevalent (79.5%) genotype identified in our study population, followed by genotypes A (18.2%) and C (2.3%). The following subtypes were isolated: ayw2 (80.7%), adw2 (14.8%), and adw (2.3%). The HBV-DNA viral load was higher in HBeAg-positive patients than it was in patients who were HBeAg-negative. Precore mutants were found in 51 (58.0%) of 88 patients. Mutations in the basal core promotor were found in 22 (25.3%)...Continue Reading

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Citations

Dec 9, 2014·Jundishapur Journal of Microbiology·Manoochehr MakvandiMohammad Jafar Yad Yad
May 13, 2015·Jundishapur Journal of Microbiology·Nastaran AnsariAli Reza Samarbaf-Zadeh
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Oct 22, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ahmed A Al-QahtaniMohammed N Al-Ahdal
Jan 25, 2021·Journal of Infection and Public Health·Alkhansa AlshabiImran Ali Khan
May 28, 2021·Journal of Family Medicine and Primary Care·Ahmad FarooqMuhammad Arshad

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Datasets Mentioned

BETA
AF046996

Methods Mentioned

BETA
ELISA
PCR
genotyping

Software Mentioned

PASW Statistics
Geneious

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