Hepatitis B virus genotypes, core gene variability and ethnicity in the Pacific region

Journal of Hepatology
Mohammed S JazayeriW F Carman

Abstract

The world-wide distribution of hepatitis B virus (HBV) genotypes follows a geographic pattern under the influence of ethnic background. Forty eight core genes from four pacific islands were compared with the following findings. First, island-specific variant substitutions were found for only two out of four islands. Second, 11 amino acid and 90 nucleotide changes specific for pacific genotypes C and D were defined. Third, the nucleotide diversity of genotype C (all but one were silent) was greater than that of genotype D. These results suggest an early appearance of genotype C in the pacific with few subsequent amino acid changes because of shared immunological responses across the region followed by random silent changes, some of which reflect isolation of individual island populations. Genotype D appeared later.

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Citations

May 16, 2013·Hepatitis Monthly·Maryam VaezjalaliHossein Goudarzi
May 1, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ren ZhangYun-Shao He
Sep 19, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dimitrios ParaskevisAngelos Hatzakis
Dec 17, 2009·Journal of Viral Hepatitis·S M JazayeriW F Carman
Feb 17, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Fuat KurbanovMasashi Mizokami
Feb 8, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Rodolfo H CamposFlavia G Pineiro Y Leone
Sep 10, 2013·Seminars in Cancer Biology·Stephen LocarniniLilly Yuen
Jun 29, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Meifang HanKathy Jackson
Jun 29, 2007·Journal of Medical Virology·Jinlin HouNikolai V Naoumov
Jun 10, 2010·Journal of Viral Hepatitis·W G E Cooksley

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