Abstract
The hepatitis B virus (HBV) genotypes distribution and the core promoter (CP)/precore (PC) variability were evaluated by a line probe assay in 272 patients infected chronically enrolled consecutively in an area of the North-Eastern Italy. Seven out of the eight genotypes were detected. Italian subjects (83% of the sample) were infected mainly by genotype D (73%) and A (26%); genotype F, and genotype H, were detected only in one subject. In foreigners, the genotype distribution reflected the distribution described for the areas of origin, that is, in Asia genotypes B, C, and D; in Africa genotypes A and E. CP and PC variants prevalence rates were 51% and 60%, respectively, and were significantly higher in Italian patients, probably in relation to their older age. In the analysis restricted to genotypes A and D, PC wild type was linked strongly to genotype A (OR = 4.08, 95% CI = 3.07-5.43, P < 0.0001). In genotype A-infected patients, only e seroconversion was associated significantly with CP variants. In genotype D-infected subjects, CP variants were linked significantly to older age and to a higher e seroconversion rate, while PC variants also showed a strong relationship with an ALT lower activity and a lower viral load. In mu...Continue Reading
References
Oct 1, 1988·The Journal of General Virology·H OkamotoM Mayumi
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·A S LokS Greene
Feb 1, 1994·Virology·H NorderL O Magnius
Jun 1, 1997·The Journal of Infectious Diseases·M LindhA Gusdal
Jul 1, 1997·The Journal of General Virology·S M BowyerJ G Sim
Mar 9, 1999·The Journal of Infectious Diseases·M LindhP Horal
Dec 22, 1999·Journal of Viral Hepatitis·C MayeratP C Frei
Jan 21, 2000·The Journal of General Virology·L StuyverR Rossau
Jul 8, 2000·Microbes and Infection·I Borchani-ChabchoubR Mokdad-Gargouri
Oct 6, 2000·Journal of Hepatology·C GrandjacquesF Zoulim
Feb 27, 2001·Intervirology·X DingM Nakanishi
Aug 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E OritoM Mizokami
Jan 29, 2002·Archives of Virology·E AlestigM Lindh
Feb 7, 2002·Journal of Hepatology·Jia-Horng KaoDing-Shinn Chen
Mar 27, 2002·Journal of Biomedical Science·C J LiuD S Chen
Apr 23, 2002·Journal of Gastroenterology and Hepatology·Varsha ThakurShiv Kumar Sarin
Jul 19, 2002·The Journal of General Virology·Patricia Arauz-RuizLars O Magnius
Sep 5, 2002·Archives of Virology·A QuinteroF H Pujol
Sep 5, 2002·Journal of Medical Virology·L V SánchezA Panduro
Nov 28, 2002·Gastroenterology·José M Sánchez-TapiasJuan Rodés
Aug 2, 2003·Gastroenterology·Chi-Jen ChuAnna S F Lok
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chi-Jen ChuUNKNOWN U.S. HBV Epidemiology Study Group
Oct 16, 2004·Clinics in Liver Disease·Chun-Tao Wai, Robert J Fontana
Oct 16, 2004·Enfermedades infecciosas y microbiología clínica·José María Echevarría, Pilar León
Nov 27, 2004·Intervirology·Helene NorderLars O Magnius
Feb 22, 2005·Journal of Viral Hepatitis·S Schaefer
Feb 22, 2005·Vox Sanguinis·F DavidsonB C Dow
Mar 9, 2005·Vaccine·Anna KramvisGuido François
Apr 19, 2005·Journal of Medical Virology·José M EchevarríaLars O Magnius
Aug 20, 2005·Journal of Viral Hepatitis·A Kramvis, M C Kew
Citations
Nov 16, 2010·Virology Journal·Alcione O SantosJuan M Salcedo
Dec 23, 2008·Enfermedades infecciosas y microbiología clínica·Julie SheldonVicente Soriano
Feb 7, 2007·Virus Research·Marisol Devesa, Flor H Pujol
Jul 14, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Anna Kramvis, Michael C Kew
Jul 14, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Stephan Schaefer
Apr 27, 2011·Journal of Medical Virology· AakankshaP Kar
Sep 29, 2009·Journal of Viral Hepatitis·N CoppolaE Sagnelli
Feb 17, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Fuat KurbanovMasashi Mizokami
Jul 2, 2014·Journal of Medical Virology·Caterina SagnelliNicola Coppola
Feb 24, 2015·Infection·Ornella ZuccaroUNKNOWN Study Group
Jul 8, 2008·Journal of Hepatology·Daniel CandottiJean-Pierre Allain
Jul 25, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Donatella FerraroRosa Di Stefano
Mar 19, 2014·PloS One·Amit TutejaSubrat K Acharya
Aug 15, 2015·PloS One·Carolina Souza GusattiMaria Lucia Rosa Rossetti
Oct 3, 2013·PloS One·Vincent ThibaultDenise Antona
Jan 10, 2018·Journal of Medical Virology·Alessia LaiMassimo Ciccozzi
Feb 26, 2008·Journal of Medical Virology·Francesco VitaleNino Romano
Apr 8, 2015·World Journal of Hepatology·Catherine Mn CroaghSally J Bell
Jan 30, 2020·BMC Infectious Diseases·Roberto BruniAnna Rita Ciccaglione
Jul 7, 2020·BioMed Research International·Salma MadihiAbdelouaheb Benani