Hepatitis B virus-induced liver fibrosis and cirrhosis: the value of liver and spleen volumetry with multi-detector spiral computed tomography

Journal of Digestive Diseases
Wei Xia LiQing Xie

Abstract

To study the correlation of liver and spleen volume with the degree of liver fibrosis and cirrhosis induced by hepatitis B virus infection. 128 participants who had undergone liver and spleen volumetry were enrolled. The control group consisted of 41 participants who were potential living liver donors. The liver fibrosis group consisted of 63 histologically proved liver fibrosis patients who were further divided into two subgroups: 44 patients with slight liver fibrosis, and 19 patients with advanced liver fibrosis. The liver cirrhosis group consisted of 24 patients. The following parameters were determined by multi-detector spiral computed tomography (MSCT) examination: total liver volume (TLV), right liver lobe volume (RV), left lateral liver segment volume (LLV), left medial liver segment volume (LMV), caudate lobe volume (CV), and spleen volume (SV). The ratios of CV to TLV (C/T), RV to TLV (R/T), LLV to TLV (LL/T), LMV to TLV (LM/T), and SV to TLV (S/T) were calculated. TLV, RV, LMV tended to decrease and SV, C/T, S/T tended to increase gradually with the increased degree of fibrosis. C/T >or= 3.34% and S/T >or= 47.36% were identified as the cut-off values of fibrosis >or=F3 (advanced liver fibrosis) and cirrhosis, respect...Continue Reading

Citations

Nov 22, 2016·Nihon Hoshasen Gijutsu Gakkai zasshi·Kohei HaradaTatsuya Imai
Jun 2, 2017·Physics in Medicine and Biology·Oliver GlogerHenry Völzke
Nov 7, 2018·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Kemal Murat HaberalMehmet Coşkun

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