Hepatitis B virus infection and risk of non-alcoholic fatty liver disease: A population-based cohort study

Liver International : Official Journal of the International Association for the Study of the Liver
Liguo ZhuFengcai Zhu

Abstract

Although non-alcoholic fatty liver disease (NAFLD) has been studied extensively, the potential risk factors for NAFLD among chronic hepatitis B (CHB) patients have not been fully known. A population-based cohort of adult CHB patients without a history of alcohol drinking or NAFLD were recruited and followed up from October 2012 to January 2015 in Jiangsu province, China. Using Cox proportional hazards regression model, potential risk factors including viral and metabolic factors for NAFLD were evaluated. Two thousand three hundred and ninety-three adult CHB patients (mean age 50.7 ± 13.2 years) were included in the cohort. With 4429 person-years of follow-up, 283 individuals progressed to NAFLD with an incidence rate of 63.89/1000 person-years. Overweight and obese CHB patients had an increased risk of NAFLD (overweight adjusted hazard ratio [HR], 3.10; 95% CI, 2.29-4.18; obese HR, 8.52; 95%CI, 5.93-12.25) compared to normal weight carriers. The incidence of NAFLD was associated with concurrent type 2 diabetes mellitus (DM) (HR, 1.88; 95%CI, 1.15-3.08). However, no associations between viral factors with NAFLD incidence rate were identified. In a subgroup of participants with concurrent type 2 DM, detectable HBV DNA levels were...Continue Reading

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Citations

Sep 20, 2018·Clinical and Molecular Hepatology·Mi Young JeonSeung Up Kim
Dec 29, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Thomas WorlandChristopher Leung
Feb 6, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Liguo ZhuFengcai Zhu
Jan 7, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Jianbin ZhangJiangao Fan
Feb 16, 2021·World Journal of Gastroenterology : WJG·Ming-Fang WangYou-Bing Li
Jul 31, 2021·World Journal of Gastroenterology : WJG·Yi-Wen ShiJian-Gao Fan
Jul 20, 2021·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Xiu-Juan ChangJian-Gao Fan
Oct 15, 2021·Cannabis and Cannabinoid Research·Tangui BarréUNKNOWN ANRS/AFEF Hepather Study Group

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