PMID: 9537850Apr 16, 1998Paper

Hepatitis B virus precore mutants in serum and liver of Southern African Blacks with hepatocellular carcinoma

Journal of Hepatology
A KramvisS Bukofzer

Abstract

The aim of this study was to sequence the precore region of HBV isolated from serum and tumorous and non-tumorous liver tissue from patients with hepatocellular carcinoma to identify mutations that might play a role in malignant transformation. HBV DNA was extracted from 62 sera, 14 tumorous and 12 non-tumorous liver tissue samples of patients with hepatocellular carcinoma, amplified by the polymerase chain reaction and sequenced directly. Thirty-nine patients were HBeAg-negative and 23 HBeAg-positive. Missense mutations were present predominantly in HBeAg-negative sera. The most common missense mutation, a guanine to thymine transversion, occurred at nucleotide 1862 in the bulge of the encapsidation signal; it was more prevalent in HBeAg-negative (10/39) than in HBeAg-positive patients (1/23) (p = 0.03). Mutations known to prevent HBeAg synthesis were detected in seven sera; five with an 1896 stop-codon mutation, one with an 1817 nonsense mutation, and one with a frameshift mutation caused by an insertion between 1838 and 1839. Missense mutations and deletions were present more often in tumorous tissue derived from HBsAg-negative patients. In the tumours missense mutations occurred at position 1862 and 1899, and the deletions ...Continue Reading

References

Jan 1, 1990·Virology·I F LoncarevićC H Schröder
Jul 11, 1990·Nucleic Acids Research·J L CasanovaP Kourilsky
May 18, 1989·Nature·S Kwok, R Higuchi
Jul 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E SongM C Kew
Feb 25, 1984·Journal of Molecular Biology·G von Heijne
Jun 1, 1983·European Journal of Biochemistry·G von Heijne
Dec 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Rodriguez-FriasJ Guardia
Mar 1, 1995·Journal of Medical Virology·T ValliammaiT J Harrison
Jan 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H P DienesK H Meyer zum Büschenfelde
Sep 1, 1994·Journal of Hepatology·J M López-AlcorochoJ L Vázquez-Iglesias
Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P PaterliniC Brechot
Mar 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M A LoriotJ P Benhamou
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·A S LokS Greene
Jul 1, 1993·Research in Virology·M ClementiI Bearzi
Jan 1, 1994·Journal of Viral Hepatitis·D Moradpour, J R Wands
Jan 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A KramvisE Song

❮ Previous
Next ❯

Citations

Jul 17, 2001·International Journal of Experimental Pathology·P Arbuthnot, M Kew
Dec 19, 1998·Journal of Viral Hepatitis·A Kramvis, M C Kew
Dec 22, 1999·Journal of Viral Hepatitis·A Kramvis, M C Kew
Jun 26, 2001·Journal of Gastroenterology and Hepatology·S K SarinB C Das
May 6, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fuminaka SugauchiMasashi Mizokami
Oct 16, 2008·Journal of Gastroenterology and Hepatology·Michael C KewRaquel Viana
May 11, 2002·Journal of Cellular and Molecular Medicine·C Kreutz
Jan 11, 2014·World Journal of Gastroenterology : WJG·Deepak GopalakrishnanAnna Kramvis
Jul 20, 2010·Clinics in Liver Disease·Brian J McMahon
Jan 19, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Chien Yu ChenAnna Kramvis
Jul 14, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Anna Kramvis, Michael C Kew
Dec 2, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Rosamar E F RezendeAna L C Martinelli
Dec 25, 2010·Journal of Medical Virology·Zandiswa GulubeAnna Kramvis
Nov 13, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Osamu YokosukaMasatoshi Kudo
May 7, 2014·Journal of Medical Virology·Liping ShenShengli Bi
Jul 24, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Rajesh PanigrahiRunu Chakravarty
Apr 5, 2017·Tropical Medicine & International Health : TM & IH·Jennifer GrantClaudia Hawkins
Sep 7, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yasuhito TanakaMasashi Mizokami
Feb 23, 2010·European Journal of Gastroenterology & Hepatology·Robert WelschingerMotasim Badri
Sep 14, 2017·Memórias do Instituto Oswaldo Cruz·Silvana Gama Florencio ChacháAna de Lourdes Candolo Martinelli
Mar 16, 2006·Current Hematology Reports·David Green

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.