Hepatitis B virus reactivation in adjuvant chemotherapy for breast cancer

Breast Cancer : the Journal of the Japanese Breast Cancer Society
Yoshimi IdeKiyohiko Hatake

Abstract

Immunosuppressive therapy, such as chemotherapy or the use of corticosteroids, may stimulate reactivation of hepatitis B virus (HBV). Most of these episodes occur in patients whose hepatitis B surface antigens are positive (HBsAg+). We report a case of HBV reactivation in a patient with negative HBsAg during chemotherapy for breast cancer, in spite of avoiding corticosteroids. A 68-year-old woman received adjuvant chemotherapy for breast cancer. Her serological examinations showed that HBsAg, HBeAg, and HBV-DNA were all negative. Her chemotherapy consisted of CAF (cyclophosphamide 500 mg/m(2), doxorubicin 50 mg/m(2), fluorouracil 500 mg/m(2)) without administration of corticosteroids. She received six cycles of CAF. At day 27 after her sixth CAF, she was admitted to the hospital with acute hepatitis B virus (HBV) reactivation. She received glycyrrhizinic acid by intravenous injection (80 mg/day), ursodeoxycholic acid (300 mg/day), and entecavir (0.5 mg/day). Then she received interferon by intravenous injection (3 million units/day), prednisolon by intravenous injection (45 mg/day), and plasma exchange therapy. However, she died of liver failure. This is a rare case in which HBV reactivation occurred in an HBsAg negative patien...Continue Reading

References

Jun 18, 2003·Journal of Clinical Gastroenterology·Nicole D SimpsonAijaz Ahmed
Nov 30, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·M S DaiT Y Chao
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Citations

Oct 7, 2010·Journal of Gastroenterology·Shigeru KusumotoMasashi Mizokami
Mar 28, 2013·Hepatitis Research and Treatment·Mehdi Zobeiri
Jan 30, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hideaki TakahashiMasashi Mizokami
Nov 3, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C S VoicanR Coriat
Jun 2, 2016·The American Journal of Case Reports·Purva ChhibarJen Chin Wang

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