Hepatitis B virus-related glomerulonephritis: not a predominant cause of proteinuria in korean patients with chronic hepatitis B

Gastroenterology Research and Practice
Jeong-Ju YooHyo-Suk Lee

Abstract

Background/Aims. Hepatitis B virus (HBV) can form immune complexes which may result in various types of glomerulonephritis (GN). However, proteinuria can occur because of other kidney diseases besides HBV-related GN (HBV-GN). The aim of this study is to elucidate the causes of proteinuria and report on the clinical outcomes of HBV-GN. Methods. We reviewed the medical records of patients positive for serum hepatitis B surface antigen who underwent renal biopsies due to proteinuria at a tertiary medical center in Korea. Results. A total of 55 patients were included. HBV-GN was diagnosed in 20 (36.4%) of the patients by confirming the presence of immune complexes (12 of 13 membranoproliferative glomerulonephritis, 7 of 8 membranous glomerulonephritis, and 1 of 13 immunoglobulin A nephropathy). Twenty-one patients had other types of GN. A total of 13 (65%) HBV-GN patients were treated with antiviral agents for a median of 11 months. However, the degrees of proteinuria were not significantly reduced in the antiviral intervention group when compared to the control group. Conclusions. Proteinuria can be caused by various glomerular diseases and HBV-GN accounts for one-third of total GN cases. Well-designed prospective study is needed ...Continue Reading

References

Jul 1, 1975·The American Journal of the Medical Sciences·D J Gocke
Dec 1, 1979·The Journal of Pediatrics·C KleinknechtV Courtecuisse
Apr 30, 2003·Archives of Disease in Childhood·F L ConnorT D Bohane
Apr 30, 2003·Archives of Disease in Childhood·G FillerN Le Saux
Feb 28, 2004·American Journal of Nephrology·Rajendra Bhimma, Hoosen Mohamed Coovadia
Aug 8, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fatih Dede, Deniz Ayli
Aug 22, 2006·Alimentary Pharmacology & Therapeutics·F FabriziP Martin
Apr 7, 2010·The Korean Journal of Hepatology·Hee Bok ChaeHyung Joon Yim
Feb 6, 2010·World Journal of Gastroenterology : WJG·Yu ZhangFeng-Yu Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

PASW

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.