Hepatitis B virus variant with the a194t substitution within reverse transcriptase before and under adefovir and tenofovir therapy

Clinics and Research in Hepatology and Gastroenterology
Julien DupoueyPhilippe Colson

Abstract

Retrospective analysis of our local HBV reverse transcriptase (rt) sequence database including 973 sequences recovered from 616 patients identified one unique HBV DNA sequence harbouring amino acid (aa) substitution rtA194T, which has been suspected to confer reduced susceptibility to tenofovir but whose implication in antiviral resistance has not been confirmed. This sequence has been recovered from the blood sample of a 35-year-old man presenting with chronic hepatitis B and cirrhosis, at time of initiation of HBV therapy with adefovir (ADV). Retrospective analysis showed that viruses were rt194A eleven months earlier. Nonetheless, rt sequences recovered from the two sequential serum samples showed 98% nucleotide identity and were clustered in phylogenetic reconstruction. Clonal sequencing was performed retrospectively, which showed that rt194A HBV sequences were the only detected in the earliest sample and rt194T HBV sequences were the only detected in the later sample. HBV rtA194T mutants were still the majoritary quasi-species 17 months after being identified for the first time. HBV genotype determined by means of population sequencing then phylogeny reconstruction was E. HBV harboring a rt194T can be naturally observed, a...Continue Reading

References

Jun 28, 2006·Antimicrobial Agents and Chemotherapy·William E DelaneyMichael D Miller
Feb 18, 2009·World Journal of Gastroenterology : WJG·Rebecca PastorEvelyne Schvoerer
Mar 6, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Samad Amini-Bavil-OlyaeeFrank Tacke
Jul 20, 2010·Clinics in Liver Disease·Stephen Locarnini, Scott Bowden

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Citations

Jan 18, 2013·World Journal of Gastroenterology : WJG·Zhuo-Lun SongHong Zheng
Feb 24, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Souleymane BrahPhilippe Colson
Sep 28, 2018·Folia Microbiologica·Sema AlacamAli Agacfidan

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