Hepatitis B virus variants in an HIV-HBV co-infected patient at different periods of antiretroviral treatment with and without lamivudine

BMC Infectious Diseases
Eneida A SantosSelma A Gomes

Abstract

Lamivudine inhibits replication of both human immunodeficiency virus (HIV) and hepatitis B virus (HBV) and is commonly used as part of antiretroviral therapy. The main limitation in the use of lamivudine is resistant mutation selection. Most of these mutations affect the YMDD motif of the HBV DNA polymerase. The resistance occurs through M550V or M550I aminoacid replacements. The M550V variation may be accompanied by L526M mutation, notably in HIV-HBV co-infected patients. The aim of this study was to investigate mutations associated with lamivudine resistance in a hemodialysis patient chronically co-infected with HIV-1 and HBV, who was submitted to several antiretroviral treatments. HBV isolates derived from three blood samples collected at different times of antiretroviral therapies with and without lamivudine, were titred and submitted to nucleotide sequencing. HBV isolate derived from a sample collected in 1999 during an antiretroviral treatment with lamivudine showed the lamivudine resistant double mutation (L526M, M550V). However, no mutation associated with lamivudine resistance was observed in the HBV genome derived from the sample collected during a period of treatment without lamivudine (2001). After reinstitution of ...Continue Reading

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Citations

Apr 19, 2012·Memórias do Instituto Oswaldo Cruz·Francisco Campello do Amaral MelloSelma de Andrade Gomes
Oct 15, 2010·Memórias do Instituto Oswaldo Cruz·Adriana Cristina da SilvaMaria Cássia Jacintho Mendes-Correa
Apr 12, 2016·Journal of Medical Virology·Marina Pedroso OliveiraRegina Maria Bringel Martins

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Datasets Mentioned

BETA
J02201
X51970

Methods Mentioned

BETA
PCR

Software Mentioned

PILEUP Analysis Package GCG
TREECON

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