Hepatitis C and the leptin system: bound leptin levels are elevated in patients with hepatitis C and decrease during antiviral therapy

Scandinavian Journal of Gastroenterology
A WidjajaG Brabant

Abstract

Serum leptin levels are elevated in alcoholic liver cirrhosis and thus might be involved in the anorexia and hypermetabolism often seen in those patients. We hypothesized that the leptin system is modulated in patients with hepatitis C and might be affected by antiviral therapy. The aim of this study was to investigate the different leptin components in serum of patients with hepatitis C before, during and after interferon alpha and ribavirin therapy and in controls. 25 patients (11 female, 14 male) with chronic hepatitis C were compared with body mass index, gender and age-matched controls (n = 25). Patients were treated with interferon alpha alone (3 MU tiw) or in combination with ribavirin for 6-12 months. Free leptin and bound leptin levels were measured using specific radioimmunoassays before interferon therapy, at 12 weeks of therapy and after 3 months of follow-up. Free leptin levels were higher in female than in male subjects, both for patients (P < 0.01) and controls (P < 0.05). Bound leptin levels were elevated in both female (P < 0.05) and male (P < 0.001) patients compared to controls. No alteration of free leptin levels was found during therapy, whereas bound leptin levels decreased after 3 months of therapy (P < 0...Continue Reading

References

Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
May 1, 1993·Seminars in Liver Disease·C McClainA M Diehl
May 1, 1996·The Journal of Clinical Investigation·C GrunfeldK R Feingold
Feb 15, 1996·Nature·G H LeeJ M Friedman
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·H BaumannL A Tartaglia
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·T GainsfordD J Hilton
Jan 30, 1997·The New England Journal of Medicine·J H Hoofnagle, A M di Bisceglie
Feb 1, 1997·The Journal of Clinical Endocrinology and Metabolism·A WidjajaG Brabant
Aug 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H C BodenheimerL B Seeff
Dec 17, 1997·The Journal of Clinical Endocrinology and Metabolism·M S ZumbachP P Nawroth
Mar 26, 1998·Biochemical and Biophysical Research Communications·J J PotterF A Anania
Aug 29, 1998·Journal of Hepatology·A J CzajaS B Moore
Sep 30, 1998·Gastroenterology·A J McCulloughS C Kalhan

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Citations

Mar 5, 2008·Alimentary Pharmacology & Therapeutics·J J Blonsky, S A Harrison
Mar 15, 2006·Journal of Hepatology·Theodoros A ZografosGeorge N Dalekos
May 27, 2011·BMC Blood Disorders·Bamidele A IwalokunPhillip U Agomo
Jun 18, 2003·The American Journal of Gastroenterology·K PatelH M Patton
Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shivakumar ChitturiJacob George
Jun 18, 2003·The American Journal of Gastroenterology·Manuel Romero-GómezAntonio Robles
Aug 20, 2005·Journal of Viral Hepatitis·M S SeyamD J Mutimer
Jul 28, 2017·European Journal of Gastroenterology & Hepatology·Nasser MousaWaleed Eldars

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