Hepatitis C-Associated B-cell Non-Hodgkin Lymphoma: A Pictorial Review

Ultrasound Quarterly
Laura IliescuLetitia Toma

Abstract

Hepatitis C virus (HCV) can induce both hepatic and extrahepatic malignancies. A strong association between HCV and non-Hodgkin lymphomas (NHLs) has been demonstrated. The purpose of this article is to give emphasis on the clinical and imagistic particularities of the hepatitis C-associated NHL, revealing the importance of ultrasonography in discovering and characterizing splenic masses. We present the cases of 3 women (aged 72, 61, and 56 years, respectively), all of which had a history of chronic hepatitis C and were subsequently diagnosed with different forms of lymphoma. In all 3 cases, conventional ultrasound exploration showed inhomogeneous splenomegaly. Contrast-enhanced ultrasound and computerized tomography were performed soon after admission, both clinical and imaging findings leading to the suspicion of lymphoma. The bone marrow biopsy was relevant for the diagnosis lymphoma in 2 patients, whereas the third woman only presented age-related changes in cellularity. Splenectomy was later performed in this case, for both diagnostic and therapeutic purposes; histopathological examination and immunohistochemistry revealed malignant non-Hodgkin diffuse large B-cell lymphoma. The cooccurrence of HCV infection and splenic lym...Continue Reading

References

May 1, 1991·AJR. American Journal of Roentgenology·C GoergK Goerg
Dec 22, 1999·European Radiology·M Schneider
Sep 13, 2006·Ultrasound in Medicine & Biology·Fabio PiscagliaUNKNOWN Italian Society for Ultrasound in Medicine and Biology (SIUMB) Study Group on Ultrasound Contrast Agents
Mar 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN American Association for the Study of Liver Diseases
Aug 30, 2011·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·F PiscagliaH P Weskott

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Citations

May 31, 2021·Ultrasound in Medicine & Biology·Corinna TrenkerChristoph F Dietrich
Jul 14, 2021·Clinical and Experimental Medicine·Letitia TomaAdriana Mercan-Stanciu

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