Hepatitis C-associated osteosclerosis: late onset after blood transfusion in an elderly woman

The Journal of Clinical Endocrinology and Metabolism
J L ShakerM P Whyte

Abstract

A 69-yr-old woman with hepatitis C virus (HCV) infection from blood transfusion 14 yr earlier was evaluated in 1997 for increasing appendicular skeletal pain. Diffusely elevated radioisotope uptake on bone scanning had appeared during the past 15 months. Radiographs spanning 1978-1997 showed remarkable restoration of bone mass and a skeleton like that of a young woman. Bone mineral densities of the femoral neck and lumbar spine were above the mean peak bone mass of young women (T scores, +1.8 and +1.3, respectively) and 160% and 147% of mean values for age-matched female controls (Z-score, +3.7 and +3.6, respectively). Biochemical markers of skeletal remodeling were substantially increased. Bone marrow biopsy showed normal lamellar bone. Serum alkaline phosphatase activity assays suggested that accelerated skeletal turnover began 6-12 months before symptoms. HC-associated osteosclerosis has been reported in nine individuals 27-73 yr of age, most with a history of i.v. drug abuse. Our patient demonstrates that parenteral exposure to blood rather than illicit drugs is the feature common to all affected subjects. Furthermore, we document that there can be a long latency between HCV infection and the development of skeletal abnorma...Continue Reading

Citations

Apr 11, 2014·Skeletal Radiology·Narendranath Epperla, Fergus E McKiernan
Nov 1, 2006·The Journal of Experimental Medicine·Edward K ChowGenhong Cheng
May 24, 2006·Endocrine Journal·Tokuji TanakaJun Hashimoto
Apr 19, 2011·Joint, Bone, Spine : Revue Du Rhumatisme·Rose-Marie JavierJean Sibilia
Apr 8, 2014·Journal of Bone Metabolism·Emilio González-ReimersF Santolaria-Fernández
Oct 4, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Etah S KurlandMichael P Whyte
Apr 17, 2008·Skeletal Radiology·Kara M Schwartz, John A Skinner
Jun 29, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C E FioreP Pennisi
Dec 8, 2004·Clinical Rheumatology·Paolo ManganelliMario Pedrazzoni
Mar 12, 2005·Arquivos brasileiros de endocrinologia e metabologia·Rodrigo O MoreiraMaria Lucia F Farias
Apr 5, 2005·Clinical Orthopaedics and Related Research·Rainer KlugerBorislava G Pavlova

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