Hepatitis C core antigen in Polish blood donors

Transfusion
M LetowskaA Rosiek

Abstract

The goal of this study was to evaluate the feasibility of adopting the HCV core antigen ELISA (HCVcAg) for routine screening of Polish blood donors. A total of 133,279 donor samples were tested by ORTHO HCVcAg. All repeatedly reactive (RR) samples were tested by neutralization test for confirmation, RIBA HCV for anti-HCV, and by Cobas Amplicore for HCV RNA. All donations were tested for ALT level. The HCVcAg test specificity was 99.94 percent. In total, 1499 donations (1.12%) were initially reactive and 124 (0.09%) were RR. Antibodies to HCV were found in 22 out of 124 donors and HCV RNA was detected in 19 out of 22. In 10 out of the 19 HCV-RNA-positive donors, the HCVcAg neutralization test was positive. Among the 102 HCVcAg RR/anti-HCV-negative donors, there were 6 neutralization-test-positive individuals, and all were HCV RNA positive. Elevated ALT level was observed in one of them. During the follow-up studies of three HCVcAg RR/HCV-RNA-positive donors, seroconvertion was observed 5 to 7 weeks after the initial HCVcAg-positive result. In all, HCVcAg results became negative once antibodies to HCV were detected. The HCVcAg test proved to be feasible for routine screening in the Polish Blood Transfusion Service. Six HCVcAg RR/...Continue Reading

References

Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M J Alter
Jul 30, 1999·Transfusion Medicine Reviews·P Flanagan, J Barbara
Feb 1, 2000·The American Journal of Medicine·I Williams
Nov 3, 2000·Transfusion·S L StramerD M Strong
Jul 7, 2001·The New England Journal of Medicine·G M Lauer, B D Walker
Sep 12, 2001·Transfusion·P L PiccoliG Aprili
Oct 19, 2002·Transfusion·C Micha NüblingJohannes Löwer

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Citations

Nov 30, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ewa BrojerUNKNOWN Polish Blood Transfusion Service Viral Study Group
Jan 18, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Katja SemeAdriana Vince
Sep 20, 2016·Journal of Hepatology·Philippa J Easterbrook, UNKNOWN WHO Guidelines Development Group

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