PMID: 9179772Jun 1, 1997Paper

Hepatitis C (HCV) genotype and viral titer distribution among Argentinean hemophilic patients in the presence or absence of human immunodeficiency virus (HIV) co-infection

Journal of Medical Virology
G R PicchioD Mosier

Abstract

Hepatitis C (HCV) infection is frequent among hemophilic patients treated with non-inactivated factor-concentrates. Both HCV genotype and viral load have been suggested to be important prognostic markers of disease progression and treatment outcome. In addition, co-infection with the human immunodeficiency virus (HIV) has been associated with increased level of HCV replication and higher risk of developing liver failure. Thus, HCV genotype, viral load, and HIV co-infection are important factors in HCV infection. Using restriction fragment length polymorphism analysis (RFLP) and the branched-DNA (bDNA) assay, we retrospectively investigated the HCV genotypes and viral loads present in 59 Argentinean hemophiliacs, in the presence or absence of HIV infection. HCV genotype 1 was the predominant viral variant detected among HIV-negative (HIV-) (76%) and HIV-positive (HIV+) (82.5%) patients, followed by genotypes 3 (10.4%), 2 (2%) and a small proportion of multiply co-infected patients including genotypes 4 and 5 (6.25%). HIV+ patients had higher plasma HCV RNA levels than HIV- patients (88.4 +/- 16.5 x 10(5) Eq/ml vs. 24.7 +/- 10(5) Eq/ml) (P < 0.001); however, no correlation between HCV replication and level of immune suppression, ...Continue Reading

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Citations

Apr 28, 2001·Journal of Clinical Microbiology·V AlfonsoR H Campos
Mar 9, 2004·Journal of Clinical Microbiology·María Inés GismondiMaría Victoria Preciado
Oct 15, 2013·World Journal of Gastroenterology : WJG·Noemí del PinoJosep Quer
Feb 16, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kazuhiko KoikeSatoshi Kimura
May 29, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·C ParodiP Baré
Feb 8, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Juan Cristina
Feb 8, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Mirta RemesarAna Del Pozo
Aug 16, 2005·Archives of Medical Research·José L Cital-ZamoraGloria Maria Calderon
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M L OliveiraC F Yoshida
May 16, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R A CarmoM O C Rocha
Oct 24, 2003·The Journal of the Association of Nurses in AIDS Care : JANAC·Kenneth D Phillips, Robyn Brewer
Dec 22, 1999·Transfusion·G C OliveiraR Corrêa-Oliveira
Feb 19, 2003·Journal of Clinical Gastroenterology·Renuka Bhattacharya, Margaret C Shuhart
Oct 19, 2001·Journal of Clinical Gastroenterology·M Dodig, A S Tavill
Jul 5, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lynne StrasfeldRobert S Klein
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·M V Ragni
Jun 28, 2001·Clinical and Diagnostic Laboratory Immunology·J M Matthews-GreerW L Chang

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