Hepatitis C in healthcare personnel: secondary data analysis of therapies with direct-acting antiviral agents

Journal of Occupational Medicine and Toxicology
Claudia WestermannAlbert Nienhaus

Abstract

Hepatitis C Virus (HCV) infections are blood-borne, generally chronic and are associated with increased morbidity and mortality. The aim of this study is to describe the results of therapies with direct-acting antiviral agents (DAAs) in healthcare personnel. Secondary data analysis using data from the Statutory Accident Insurance of the Health and Welfare Service. The study surveyed DAA therapies administered to insured parties (healthcare personnel with an HCV infection recognised as an occupational disease) in Germany between 01/01/2014 and 30/11/2016. The end points were results of monitorings carried out twelve weeks after the end of treatment (SVR12), side effects and the results of the assessment of reduced work ability after treatment. Multivariate logistic regression models were constructed to model SVR12. The study population (n = 180) comprised 74% women, 90% of the participants had an HCV genotype 1 infection. Two-thirds had fibrosis or cirrhosis and were treatment experienced. The most common combined therapy was ledipasvir and sofosbuvir (49%). A DAA therapy with ribavirin was administered in 20% of cases, with (pegylated) interferon and ribavirin used in 2% of cases. The majority of therapies were completed withou...Continue Reading

References

Sep 17, 2003·Fortschritte der Neurologie-Psychiatrie·M Schäfer, M Schwaiger
May 5, 2012·Journal of Occupational Medicine and Toxicology·Albert NienhausMadeleine Dulon
Oct 23, 2012·Infectious Disease Clinics of North America·Jihad Slim, Muhammad Shoaib Afridi
Dec 3, 2014·Journal of Hepatology·Rachel H Westbrook, Geoffrey Dusheiko
Feb 18, 2015·Lancet·Daniel P WebsterGeoffrey M Dusheiko
Apr 14, 2015·Zeitschrift für Gastroenterologie·C SarrazinS Zeuzem
Jan 21, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Toshifumi TadaJunko Tanaka
Jan 29, 2016·World Journal of Gastroenterology : WJG·Rocío González-GrandeJosé Mostazo Torres
Oct 30, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patrick IngilizStefan Mauss
Oct 27, 2016·Infectious Diseases and Therapy·Roberto Nuño SolinísYuri Sanchez Gonzalez
Dec 3, 2016·Journal of Occupational Medicine and Toxicology·Claudia WestermannAlbert Nienhaus
Apr 20, 2017·Antiviral Therapy·John LubelUNKNOWN Australian Liver Association Clinical Research Network (ALA CRN)

❮ Previous
Next ❯

Citations

Mar 23, 2019·Journal of Occupational Medicine and Toxicology·Dörthe BrüggmannStefanie Mache
Jan 16, 2020·International Journal of Environmental Research and Public Health·Melanie RungeAlbert Nienhaus
Mar 19, 2020·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Max J HassensteinStefanie Castell
Aug 26, 2021·Journal of Occupational Medicine and Toxicology·Claudia WestermannAlbert Nienhaus

❮ Previous
Next ❯

Software Mentioned

Excel

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Chetan KalalSamir Shah
The New England Journal of Medicine
Anna S LokClaudio Pasquinelli
The New England Journal of Medicine
K V KowdleyION-3 Investigators
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
N R Hussein, Z S M Saleem
© 2022 Meta ULC. All rights reserved