Hepatitis C: indication for anti-viral therapy?

Transplant International : Official Journal of the European Society for Organ Transplantation
K P PlatzP Neuhaus

Abstract

Hepatitis C infection is a frequent indication for liver transplantation. In general, recurrent graft hepatitis is assumed to be mild, but may be the cause of lethal postoperative complications in a small patient population. Out of 500 transplants in 458 patients, 123 patients were transplanted due to hepatitis C infection (26.7%) between September 1988 and April 1994. Cumulative 1- to 6-year patient survival was similar for patients transplanted due to hepatitis C (87.0%) and those transplanted for other indications (86.0%). In patients with hepatitis C virus (HCV), death, in 50% of the cases, was related to HCV recurrence and chronic rejection. Four patients (25.0%) died because of severe infection and multiple organ failure syndrome unrelated to HCV recurrence and chronic rejection. The incidence of retransplantation was similar in HCV (9.8%) and other patients (8.4%). In HCV patients, 6 of 12 retransplantations (50.0%) were performed due to HCV recurrence and chronic rejection. Of 123 HCV patients, 45 experienced histologically proven recurrent graft hepatitis between 2 weeks and 5.5 years after transplantation. The incidence of acute rejection was similar in both groups. The incidence of steroid-resistant rejection was, ho...Continue Reading

References

Apr 1, 1992·The Journal of Clinical Investigation·C FérayC Bréchot
Jan 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J J PoteruchaR H Wiesner

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Citations

Jul 17, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·K P PlatzP Neuhaus

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