PMID: 8957946Nov 1, 1996Paper

Hepatitis C infection after blood product transfusion

Archives of Disease in Childhood
D A Kelly

Abstract

HCV infection has been demonstrated in multiply transfused children who received blood products or transplanted organs before universal screening in 1990. The risk of active infection is related to the number of transfusions or pooled blood products. Accurate diagnosis of infection is dependent on utilisation of third generation RIBA and identification of HCV RNA by RT-PCR. The natural history of HCV in childhood is undetermined and prospective long term studies should be undertaken. It is likely that about develop chronic hepatitis with progression at some time to cirrhosis and have an increased risk of developing liver cancer. Treatment with interferon alfa may be effective in up to 50% of children and only those children with documented infection with HCV RNA should be selected for treatment. In order to answer important questions about natural history, outcome, and the necessity and efficacy of treatment response, treatment for these children should only be as part of scientifically conducted studies on a multicentre basis.

References

Jan 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J G McHutchisonR DiNello
Feb 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L J JeffersM Houghton
May 1, 1992·Journal of Hepatology·F BortolottiM D'Addezio
Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Ruiz-MorenoV Carreño
Nov 21, 1992·Lancet·G KudesiaJ Clewley
Dec 1, 1991·The Journal of Pediatrics·P S WeintrubM M Thaler
Nov 30, 1989·The New England Journal of Medicine·G L DavisUNKNOWN Hepatitis Interventional Therapy Group
Nov 30, 1989·The New England Journal of Medicine·A M Di BisceglieJ H Hoofnagle
Oct 1, 1995·Journal of the Royal Society of Health·M I Gurr, C J Henry
Dec 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F BortolottiA Bertolini
Dec 1, 1995·American Journal of Public Health·N L Day
Dec 1, 1995·American Journal of Public Health·B LarroqueD Querleu
Nov 1, 1993·Journal of Medical Virology·M OshitaH Fusamoto
Feb 1, 1994·Transplantation·F NorolJ P Vernant
Jan 1, 1994·Scandinavian Journal of Infectious Diseases·M García-BengoecheaJ I Arenas
Dec 1, 1994·The Journal of Infectious Diseases·D L ThomasT C Quinn
Mar 1, 1995·Acta Paediatrica·M RestiA Vierucci
Jul 1, 1995·Neurotoxicology and Teratology·E L Abel
Jun 1, 1995·Journal of Abnormal Child Psychology·M T Lynskey, D M Fergusson
Feb 1, 1993·Archives of Disease in Childhood·R IorioA Vegnente
May 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Roudot-ThoravalD Dhumeaux
Dec 1, 1994·Journal of Paediatrics and Child Health·S MatsuokaY Kuroda
Oct 1, 1994·Digestive Diseases and Sciences·M J NowickiW F Balistreri
Sep 1, 1994·European Journal of Pediatrics·S CesaroF Bortolotti
Nov 26, 1994·Lancet·C L van der PoelH W Reesink
Apr 1, 1994·Journal of Clinical Gastroenterology·K R DeVaultS K Ballas
Apr 1, 1994·Journal of Virological Methods·P ParvazM Sepetjan
Apr 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M NaitoT Kamada
May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A TsubotaK Hiromitsu

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Citations

Dec 26, 2001·Journal of Pediatric Gastroenterology and Nutrition·Karen R JacobsonKathleen B Schwarz
Jul 27, 2001·Anesthesiology Clinics of North America·S L Barcelona, C J Coté

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