Hepatitis C infection, time in renal-replacement therapy, and outcome after kidney transplantation

Transplantation
A BruchfeldCarl-Gustaf Elinder

Abstract

Hepatitis C virus (HCV) infection is common in kidney transplantation and is known to affect long-term patient and graft survival, as is time in renal-replacement therapy (RRT). The aim of this study was to investigate HCV in relation to time in RRT and its impact on outcome after transplantation. A follow-up cohort study using Kaplan-Meier analysis and Cox proportional hazards model was performed in 545 kidney and 26 kidney-pancreas transplant recipients receiving transplants between 1989 and 1997, with last follow-up on December 31, 2002. HCV status at transplantation and time in RRT were analyzed. Time in RRT was significantly longer (P<0.0001), and previous transplantations were more common (P=0.04) in the HCV-positive group. HCV significantly reduced patient (P=0.0012) and graft survival (P=0.0003) after transplantation. Adjustment for age, sex, diabetes, previous transplantations, type of transplant, and time in RRT resulted in a relative risk (RR) for death of 2.23, 1.92, and 1.07 for HCV, diabetes, and age, respectively. The RR for graft loss was 1.96 and 1.03 for HCV and age. Sex, previous transplants, and time in RRT did not affect HCV as an independent risk factor for patient or graft survival. The leading cause of d...Continue Reading

References

Sep 18, 1997·Kidney International·G G Vosnides
May 1, 1997·Journal de pharmacie de Belgique
Dec 12, 1997·The Journal of Infectious Diseases·J IzopetJ Puel
Oct 17, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C O Stehman-BreenR J Johnson
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MathurinM O Bitker
Oct 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J M CampistolM Bruguera
May 16, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C MedinH Wilczek
Sep 9, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Nov 10, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G M LondonA P Guerin
Jul 31, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M EspinosaP Aljama
Mar 26, 2002·Journal of the American Society of Nephrology : JASN·Friedrich K PortRobert A Wolfe
Apr 19, 2002·Journal of the American Society of Nephrology : JASN·Roy D BloomKevin C Mange
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fabrizio FabriziPaul Martin
Sep 18, 2002·Kidney International·Fernando G CosioRonald M Ferguson
Dec 17, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Bruce Kaplan, Herwig-Ulf Meier-Kriesche
Jan 29, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K Sudhakar ReddyDinesh Ranjan
Mar 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Josep M CruzadoJosep M Grinyó
Mar 15, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kunitoshi IsekiShuichi Takishita
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Nassim KamarLionel Rostaing
Jan 2, 2004·Transplantation·Daniel SerónUNKNOWN Spanish Chronic Allograft Nephropathy Study Group

❮ Previous
Next ❯

Citations

Feb 13, 2013·International Urology and Nephrology·A R SolimanN Shaheen
Aug 27, 2011·Transplantation·Francisco López-MedranoUNKNOWN Spanish Network for the Research of Infection in Transplantation/Network of Research in Infectious Diseases (RESITRA/REIPI)
Nov 23, 2012·Transplantation·Marco CarboneJames Neuberger
Jan 26, 2011·Journal of Gastroenterology and Hepatology·Chen-Hua Liu, Jia-Horng Kao
Apr 13, 2011·Seminars in Dialysis·Andres F CarrionPaul Martin
May 19, 2012·BMJ Case Reports·Avirup ChakrabortyNilanjan Chakraborty
Dec 19, 2007·Clinical and Experimental Nephrology·Osama A GheithMohamed A Ghoneim
Jul 15, 2011·International Journal of Nephrology·Marco CarboneJames Neuberger
Jun 12, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Po-Lin TsengTsung-Hui Hu
Mar 26, 2013·Clinics and Research in Hepatology and Gastroenterology·Nassim KamarLionel Rostaing
Nov 21, 2008·Kidney International·Jon J SnyderBertram L Kasiske
Jan 5, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Marion CorougeStanislas Pol
Oct 31, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Craig E GordonAdeera Levin
Dec 20, 2007·Transplantation Proceedings·E RidruejoA Vilches
Mar 29, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Patricia L Adams
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Fabrizio FabriziGareth Dulai
Oct 4, 2005·Alimentary Pharmacology & Therapeutics·F FabriziP Martin
Aug 15, 2008·Reviews in Medical Virology·Seyed Mohammadmehdi Hosseini MoghaddamNahid Arjmand Kermani
Jul 20, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Leonardo L SchiavonMaria Lucia G Ferraz
Mar 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN American Association for the Study of Liver Diseases
Dec 8, 2007·Reviews in Medical Virology·Seema Baid-AgrawalNina Tolkoff-Rubin
Apr 28, 2006·Journal of Viral Hepatitis·A BruchfeldR Schvarcz
Nov 4, 2006·Alimentary Pharmacology & Therapeutics·F FabriziP Martin
Aug 8, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y XiaL K Kayler
Apr 11, 2014·Journal of Viral Hepatitis·F FabriziP Messa
Aug 7, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Beatriz Domínguez-Gil, Jose M Morales
May 24, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Patrizia BurraMarco Senzolo
Apr 6, 2016·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver
May 7, 2015·Current Opinion in Organ Transplantation·Vilas R Patwardhan, Michael P Curry
Jul 18, 2014·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver (KASL)
Mar 29, 2005·Diabetes Care·Matilde MasiniPiero Marchetti
May 6, 2016·Clinical Transplantation·Ashley J LimkemannGaurav Gupta
May 19, 2016·Current Opinion in Infectious Diseases·Arif M CosarAhmet Gurakar
Oct 28, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F López-MedranoUNKNOWN Spanish Network for Research in Infectious Diseases (REIPI), the Group for the Study of Infection in Transplant Recipients (

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Fabrizio FabriziGareth Dulai
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Josep M CruzadoJosep M Grinyó
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
P MathurinM O Bitker
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Fabrizio FabriziPaul Martin
© 2021 Meta ULC. All rights reserved