Hepatitis C recurrence is more severe after living donor compared to cadaveric liver transplantation

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Montserrat Garcia-RetortilloAntoni Rimola

Abstract

Preliminary reports suggested that hepatitis C virus (HCV) infection has a more aggressive course following living donor liver transplantation (LDLT) compared to cadaveric liver transplantation (CLT). The aim of this prospective study was to establish if HCV disease recurrence differs between LDLT and CLT. A cohort of 116 consecutive HCV-infected patients undergoing 117 LTs in a single center from March 2000 to August 2003 were followed-up, including systematic liver biopsies. Severe recurrence (SR) was defined as biopsy-proven cirrhosis and/or the occurrence of clinical decompensation. After a median follow-up of 22 months (2.6-44 months), 26 (22%) patients developed SR (decompensation in 12), involving 17 (18%) of 95 patients undergoing CLT and 9 (41%) of 22 undergoing LDLT. The 2-year probability of presenting SR was significantly higher in LDLT compared to CLT (45% vs. 22%, P = .019). By univariate analysis LDLT (P = .019) and an ALT higher than 80 IU/L 3 months after LT (P = .022) were predictors of SR. In 93 patients from whom a liver biopsy was available 3 months after LT, a lobular necroinflammatory score >1 (P < .01), LDLT (P < .01), and biliary complications (P = .046) were associated with SR. However, the only variab...Continue Reading

References

Jan 1, 1995·Journal of Hepatology·P J Scheuer
Sep 1, 1993·Journal of Cellular Physiology·M BocchettaA D Cooper
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S SakamotoK Kashima
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M PrietoJ Berenguer
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·V AgnelloQ X Zhang
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S J PelletierT L Pruett
Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M BerenguerJ Berenguer
May 9, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F P SarasinA Hadengue
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi Bruix, Josep M Llovet
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Montserrat Garcia-RetortilloJuan Rodes
Mar 13, 2002·Transplantation·Markus SagmeisterEberhard L Renner
Apr 20, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jeffrey S CrippinMichael R Charlton
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marina BerenguerJoaquín Berenguer
Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Domenico AlvaroEugenio Gaudio
Feb 28, 2003·The New England Journal of Medicine·Robert S BrownJay H Hoofnagle
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marina BerenguerTeresa L Wright
Oct 4, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Paul J GaglioRobert S Brown
Oct 7, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James F Trotter
Oct 7, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kim M Olthoff
Oct 7, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Christoph E BroelschMassimo Malago
Oct 7, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gregory T Everson, James Trotter
Oct 7, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Charles M Miller
Oct 7, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R Mark Ghobrial, Ronald W Busuttil
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Koichi WatashiKunitada Shimotohno
Oct 31, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Russell H WiesnerUNKNOWN International Liver Transplantation Society Expert Panel
Nov 20, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·René AdamUNKNOWN European Liver Transplant Association
Dec 4, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sasan RoayaieMyron E Schwartz
Mar 3, 2004·Digestive Diseases and Sciences·Hector Rodriguez-LunaDavid D Douglas
Mar 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mark W RussoRoshan Shrestha
Mar 16, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

❮ Previous
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Citations

Jul 26, 2012·Seminars in Immunopathology·Giacomo GermaniAndrew K Burroughs
Apr 20, 2007·Langenbeck's Archives of Surgery·J MittlerP Neuhaus
Mar 21, 2006·Journal of Hepato-biliary-pancreatic Surgery·Chi Leung Liu, Sheung Tat Fan
Mar 21, 2006·Journal of Hepato-biliary-pancreatic Surgery·Rafik Mark Ghobrial, Ronald W Busuttil
Oct 3, 2006·Journal of Hepato-biliary-pancreatic Surgery·Shigeru MarubashiMorito Monden
Apr 9, 2008·Journal of Hepato-biliary-pancreatic Surgery·Sumihito Tamura, Yasuhiko Sugawara
Apr 9, 2008·Journal of Hepato-biliary-pancreatic Surgery·Koji Hashimoto, Charles Miller
Oct 12, 2012·Surgery Today·Yasutsugu Takada, Shinji Uemoto
Apr 18, 2008·Current Gastroenterology Reports·Sonja K Olsen, Robert S Brown
Jun 1, 2005·Journal of Hepatology·Henkie P TanAmadeo Marcos
Dec 7, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·James F Trotter, Geoffrey S Jensen
Apr 9, 2005·Current Opinion in Gastroenterology·Kimberly A Brown
Sep 26, 2006·Annals of Surgery·Andrew M CameronRonald W Busuttil
Sep 24, 2005·Transplantation·Shigeru MarubashiMorito Monden
Nov 16, 2005·Transplantation·Jens EnckePeter Sauer
Sep 29, 2006·Transplantation·Sheung Tat Fan
Apr 8, 2009·Current Opinion in Gastroenterology·Catherine SkagenAdnan Said
Apr 21, 2007·Digestive Surgery·Tokihiko Sawada, Keiichi Kubota
May 11, 2012·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·A Taki-EldinS-S Zheng
Apr 13, 2007·Drugs·Mazen AlsatiePaul Y Kwo
Mar 26, 2008·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Yoichi Ishizaki, Seiji Kawasaki
Sep 12, 2012·World Journal of Gastrointestinal Pharmacology and Therapeutics·Marco CarboneLeonardo Baiocchi
Apr 8, 2014·World Journal of Gastroenterology : WJG·Renumathy Dhanasekaran, Roberto J Firpi
May 28, 2013·Clinical & Developmental Immunology·Shih-Hsien HsuShen-Nien Wang
Mar 16, 2006·European Journal of Gastroenterology & Hepatology·Bruno Roche, Didier Samuel
May 14, 2010·European Journal of Gastroenterology & Hepatology·Stefan ZschiedrichMatthias Breidert
Jul 21, 2011·European Journal of Gastroenterology & Hepatology·Zoe MariñoMiquel Angel Navasa
Aug 8, 2008·Current Opinion in Organ Transplantation·Heidi Yeh, Kim M Olthoff
Apr 28, 2009·Current Opinion in Organ Transplantation·Alexander Kuo, Norah A Terrault
Jun 30, 2009·Scandinavian Journal of Gastroenterology·Ryota MasuzakiMasao Omata
Jan 1, 2009·Expert Review of Clinical Pharmacology·Natasha Walzer, Steven L Flamm
Jul 23, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Patrizia BurraStefano Fagiuoli
Oct 14, 2011·International Journal of Hepatology·Rahul DeshpandeDavid Sherlock
Mar 29, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A TerraultUNKNOWN A2ALL Study Group
Mar 3, 2009·Medicina clínica·Alejandro FornerJordi Bruix
Jul 16, 2008·Clinics in Liver Disease·Elizabeth C Verna, Robert S Brown
May 13, 2008·Gastroenterology·Robert S Brown
Dec 7, 2007·Molecular Aspects of Medicine·Roberto MazzantiLuigi Bolondi

❮ Previous
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