PMID: 7545715May 1, 1995Paper

Hepatitis C-related chronic liver disease among asymptomatic blood donors in the north west of England

The Journal of Infection
J P McLindonT W Warnes

Abstract

In the first 19 months of screening, the North Western Regional Transfusion Centre (RTC) tested 224,000 consecutive blood donors for antibody to hepatitis C virus (anti-HCV) by second generation enzyme immunoassay (EIA). Of these, 366 repeatedly reactive samples were referred for confirmatory testing at Manchester Public Health Laboratory (PHL). There, the initial EIA was repeated, together with two further EIAs. All the referred samples were subjected to a confirmatory line immunoblot (RIBA-II). Reverse transcription followed by the polymerase chain reaction (RT-PCR), in order to detect viral RNA, was performed on selected samples. Among the donors, 61 accepted offers for medical review and were assessed for risk factors, clinical findings and results of standard liver function tests. Of these donors, 53 proceeded to liver biopsy. The overall prevalence of confirmed positive donors was 0.04%. Main risk factors identified included intravenous drug abuse in 31 (51%) donors and prior blood transfusion in 12 (20%) but a risk factor was not apparent in 11 (18%). Viraemia, detected by RT-PCR, could be predicted with a high degree of accuracy by means of the readily available and simpler screening and confirmatory tests (EIA and RIBA...Continue Reading

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Citations

Jan 6, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C PuotiF Montagnese
Oct 6, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·G LodiS R Porter
Apr 9, 1999·Sexually Transmitted Infections·G Rooney, R J Gilson
Dec 20, 2008·Pakistan Journal of Biological Sciences : PJBS·Hossein KhedmatAmir Masoud Jafari
Mar 13, 2012·Journal of Viral Hepatitis·C PuotiM G Elmo
Aug 5, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·G LodiC Scully
Jun 9, 2001·European Journal of Gastroenterology & Hepatology·S HervéP Ducrotte
Aug 31, 2002·Journal of Gastroenterology and Hepatology·Seyed Moayed AlavianSadegh Masarrat
Dec 3, 2008·European Journal of Gastroenterology & Hepatology·Janaína L Narciso-SchiavonMaria Lucia G Ferraz
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·M OhsawaK Aozasa
Oct 5, 2002·Biological Research for Nursing·Adeline NyamathiSammy Saab

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